An explanation for the protective effect of the MHC class II I-E molecule in murine diabetes

Nature
E P ReichC A Janeway

Abstract

Insulin-dependent diabetes mellitus is widely believed to be an autoimmune disease. Recent onset diabetics show destruction of insulin-secreting pancreatic beta-cells associated with a lymphocytic infiltrate (insulitis), with autoantibodies to beta-cells being found even before the onset of symptoms. Susceptibility to the disease is strongly influenced by major histocompatibility complex (MHC) class II polymorphism in both man and experimental animal models such as the non-obese diabetic (NOD) mouse. As MHC class II molecules are usually associated with dominant immune responsiveness, it was surprising that introduction of a transgenic class II molecule, I-E, protected NOD mice from insulitis and diabetes. This could be explained by a change either in the target tissue or in the T cells presumed to be involved in beta-cell destruction. Recently, several studies have shown that I-E molecules are associated with ontogenetic deletion of T cells bearing antigen/MHC receptors encoded in part by certain T-cell receptor V beta gene segments. To determine the mechanism of the protective effect of I-E, we have produced cloned CD4+ and CD8+ T-cell lines from islets of recently diabetic NOD mice. These cloned lines are islet-specific and ...Continue Reading

References

Jan 1, 1978·Advances in Metabolic Disorders·J Nerup
Oct 1, 1988·Diabetes·K HaskinsK Lafferty
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J BillE Palmer
Feb 1, 1989·Immunological Reviews·C A JanewayS Buxser
May 1, 1989·Immunology Today·E Heber-Katz, H Acha-Orbea
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·H Acha-Orbea, H O McDevitt
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·I StamenkovicJ T Kurnick
Feb 1, 1988·Journal of Immunogenetics·C A JanewayS Buxser
Apr 24, 1987·Cell·J W KapplerP Marrack
May 22, 1986·The New England Journal of Medicine·G S Eisenbarth

❮ Previous
Next ❯

Citations

Mar 1, 1991·Diabetes/metabolism Reviews·C BoitardJ F Bach
Dec 1, 1995·Diabetes/metabolism Reviews·A G Baxter, A Cooke
Jan 1, 1993·Acta Diabetologica·E J RashbaR S Sherwin
Jan 1, 1993·Immunologic Research·J F Miller
Jan 1, 1993·Immunologic Research·C Carnaud, J F Bach
May 1, 1994·Journal of the Neurological Sciences·S J HodgkinsonJ D Pollard
Apr 1, 1993·Molecular Immunology·S MécheriM K Hoffmann
Apr 1, 1990·Immunology Today·J A Todd
Apr 1, 1989·Current Opinion in Immunology·A A RossiniD L Greiner
Dec 1, 1994·Current Opinion in Immunology·D V Serreze, E H Leiter
Feb 28, 2004·Journal of Autoimmunity·Yang Yang, Pere Santamaria
Mar 31, 2000·Diabetes Research and Clinical Practice·M F McInerneyC A Janeway
Jun 1, 1997·Research in Immunology·F S Wong, C A Janeway
Jan 1, 1995·Baillière's Clinical Endocrinology and Metabolism·N M Parish, A Cooke
Jan 23, 1999·Current Opinion in Immunology·H O McDevitt
Feb 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·Taku YoshidaTaku Okazaki
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·U McKeeverA A Rossini
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S IkeharaT O Yoshida
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J A ToddT Sasazuki
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S CandéiasK Haskins
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S ForsgrenT Matsunaga
Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C BoitardJ F Bach
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S M SingerH O McDevitt
Oct 1, 1990·The Journal of Experimental Medicine·B L RellahanL A Matis
Mar 1, 1995·The Journal of Experimental Medicine·A H Shankar, R G Titus
Sep 1, 1996·The Journal of Experimental Medicine·K HashimotoT Nakayama
Jan 1, 1992·Thyroid : Official Journal of the American Thyroid Association·R S Bahn, A E Heufelder
Nov 1, 1992·European Journal of Clinical Investigation·B O Roep, R R De Vries

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Adenoma, Islet Cell

Islet Cell Adenoma arises in the islet cells, which are insulin producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on Islet Cell Adenoma here.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.