An explanation for the reduction in bilirubin levels in congenitally jaundiced Gunn rats after transplantation of isolated hepatocytes

European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
R J Woods, S P Parbhoo

Abstract

Isolated hepatocytes prepared from Wistar rats by mechanical means were infused into the liver of congenitally jaundiced Gunn rats. Red cell survival was determined in the recipients and their total plasma bilirubin was measured just before and 20 days after transplantation. Similar measurements were made in transplanted Gunn rats receiving the immunosuppressant drug cyclophosphamide at 5 mg/kg/day and in a group of splenectomized Gun rats. Red cell survival was significantly prolonged in all transplanted rats and in the splenectomised group. Total plasma bilirubin also fell significantly in all three groups by up to 25%, a change we attribute to reduced red cell turnover, haemoglobin synthesis and hence reduced bilirubin synthesis. Blockade of the splenic reticuloendothelial system by hepatocyte debris is suggested as a possible cause.

Citations

Sep 1, 1986·Annals of Surgery·A A DemetriouJ R Chowdhury
Jul 22, 2008·Molecular Genetics and Metabolism·Gregory M Enns, Maria T Millan
Nov 18, 2015·Journal of Chemical Theory and Computation·Gaspar P PintoMarirosa Toscano
Jul 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H HamaguchiM Ogawa
Jul 1, 1994·Cell Transplantation·L B JohnsonJ P Vacanti
Sep 1, 1998·Journal of Gastroenterology and Hepatology·Toshiyasu KawaharaMichio Mito

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.