An Exploration of the Rs of Radiobiology in Prostate Cancer.

Seminars in Oncology Nursing
C Roberts, C Paterson

Abstract

To explore the four Rs of radiobiology (Repair, Reoxygenation, Reassortment, and Repopulation) as a means to understand the effects of ionising radiation on biological tissue and subsequently as the basis for conventional fractionated treatment schedules. These radiobiological principles will form a rationale for combined regimens in prostate cancer treatment involving androgen deprivation therapy and radiation therapy and the associated toxicities of this approach will be discussed. Electronic databases including CINAHL, MEDLINE, Scopus, professional websites, books and grey literature were searched using Google Scholar. It is important for nurses to understand the four Rs of radiobiology to grasp the effects of ionising radiation on biological tissue as the basis for conventional fractionated treatment schedules in prostate cancer. Men can experience a sequalae of physical and psychological side effects of treatment that can negatively impact quality of life. Men can experience a range of unmet supportive care needs particularly related to informational, sexual, and psychological needs. For men affected by prostate cancer opting for radiation therapy (+/-) androgen deprivation therapy, nurses should ask targeted questions bas...Continue Reading

References

Jan 1, 1982·Radiation and Environmental Biophysics·K R Trott
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J D CoxT F Pajak
Jul 15, 2005·JAMA : the Journal of the American Medical Association·Nima SharifiWilliam L Dahut
Sep 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy L KeatingMatthew R Smith
Apr 6, 2007·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Marie TärnhuvudAnia Willman
Feb 6, 2010·Stem Cells·Frank PajonkWilliam H McBride
Sep 24, 2010·Endocrine-related Cancer·Nima SharifiWilliam L Dahut
Jul 16, 2013·Clinical Oncology : a Journal of the Royal College of Radiologists·J S Good, K J Harrington
Sep 24, 2013·Best Practice & Research. Clinical Endocrinology & Metabolism·Mathis GrossmannJeffrey D Zajac
Aug 7, 2014·European Urology·Paul L NguyenMatthew R Smith
Dec 24, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas M PisanskyHoward M Sandler
Jan 24, 2015·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Catherine PatersonGhulam Nabi
Feb 19, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Malcolm D MasonPadraig Warde
Feb 25, 2015·Nature Reviews. Urology·Jahan J MohiuddinRonald C Chen
May 28, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael BrundageMalcolm D Mason
Mar 16, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michel BollaLaurence Collette
Apr 2, 2016·Therapeutic Advances in Urology·Piotr ZarebaJehonathan H Pinthus
Apr 14, 2016·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Valeria LandoniTiziana Rancati
Jun 29, 2016·Cancer Nursing·Catherine Paterson, Ghulam Nabi
Oct 27, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Michael J ZelefskyYoshiya Yamada
Jan 22, 2017·Radiation Oncology·Carsten HerskindFrederik Wenz
Jun 8, 2017·Current Urology Reports·Greg Kauffmann, Stanley L Liauw
Jun 18, 2017·Cancer Letters·Athanasia PavlopoulouAlexandros G Georgakilas
May 23, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Kazuo HatanoKoichi Konoeda
Jun 23, 2019·Cancers·Jihane BoustaniCéline Mirjolet
Jan 9, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Kim EdmundsRobert U Newton

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