An Exploratory Analysis of Potential New Biomarkers of Cognitive Function

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Matthew J PetersonLarry W Lawhorne

Abstract

We examined the relationship between serially measured, novel serum biomarkers and a measure of cognitive functioning in older adults. We assayed stored serum samples from two Fels Longitudinal Study visits in N = 100 adult participants (visit 1 ages 59.3 ± 8.5 years; 53% female), and Montreal Cognitive Assessment (MoCA) scores also assessed at the second visit. Assays included acylcarnitines, amino acids, and 2-hydroxybutyric acid (b-HBA). Cross-sectional correlations between acylcarnitines and amino acids and MoCA were identified. Serial change in short-chain acylcarnitines and visit 2 MoCA were also correlated. Participants with MoCA scores <26 were more likely to have an increase in short-chain acylcarnitines between visits 1 and 2 [adjusted odds ratio (OR) = 5.24; 95% confidence interval (CI) 1.07-25.9]. b-HBA was also correlated with acylcarnitines. Several cross-sectional and serial associations between novel serum biomarkers and cognitive functioning were identified. b-HBA may also be a cost-effective marker of dysregulation associated with cognitive decline.

References

Mar 30, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Patrick G Sullivan, Maile R Brown
Apr 9, 2005·Journal of the American Geriatrics Society·Ziad S NasreddineHoward Chertkow
Jul 29, 2005·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·E SilveiraB Steen
Jun 17, 2008·Journal of Cellular and Molecular Medicine·Ignasi BarbaDavid Pozo
Apr 10, 2009·Molecular Systems Biology·Svati H ShahWilliam E Kraus
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jia YaoRoberta Diaz Brinton
Sep 2, 2009·Progress in Lipid Research·Lauren L JonesPeggy R Borum
Mar 4, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Helen LumMiriam C Morey
Mar 19, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·UNKNOWN Alzheimer's Association
May 6, 2011·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Giuseppe Astarita, Daniele Piomelli
Jun 15, 2012·Journal of the Neurological Sciences·Irene PiaceriSandro Sorbi
Jul 24, 2012·Molecular Neurobiology·Kristina LeunerWalter E Müller
Aug 25, 2012·Biomarkers in Medicine·Chantal Bazenet, Simon Lovestone
Jul 3, 2013·Biochimica Et Biophysica Acta·Eugenia Trushina, Michelle M Mielke
Sep 26, 2013·American Journal of Physiology. Endocrinology and Metabolism·Melanie B GillinghamJonathan Q Purnell
Dec 18, 2013·Mechanisms of Ageing and Development·Barbara CaraccioloLaura Fratiglioni
Feb 27, 2014·Bioanalysis·David Touboul, Mathieu Gaudin
Mar 13, 2014·Nature Medicine·Mark MapstoneHoward J Federoff
Apr 4, 2014·Journal of Proteome Research·Gang WangWei Jia
Jun 14, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Massimo S FiandacaHoward J Federoff
Jan 13, 2015·Journal of Pharmaceutical and Biomedical Analysis·Raúl González-DomínguezJosé Luis Gómez-Ariza
Mar 3, 2015·Nature Neuroscience·Ethan A WinklerBerislav V Zlokovic
Sep 12, 2015·International Review of Neurobiology·Clara IbáñezCarolina Simó
Jan 13, 2016·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Carlo CervellatiGiovanni Zuliani
Apr 22, 2016·The American Journal of Clinical Nutrition·Marta Guasch-FerréJordi Salas-Salvadó
Mar 7, 2017·Oxidative Medicine and Cellular Longevity·Jeddidiah W D Griffin, Patrick C Bradshaw
Apr 18, 2017·Neuroscience and Biobehavioral Reviews·Elizabeth H X ThomasCaroline Gurvich
Jul 22, 2017·International Journal of Geriatric Psychiatry·Nicole CarsonKelly J Murphy
Aug 25, 2017·Scientific Reports·Valentina Di PietroAntonio Belli

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Citations

Jan 31, 2020·Ageing Research Reviews·Richard D SembaLuigi Ferrucci

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