An exploratory model for G x E interaction on hippocampal volume in schizophrenia; obstetric complications and hypoxia-related genes

Progress in Neuro-psychopharmacology & Biological Psychiatry
Unn Kristin HaukvikIngrid Agartz

Abstract

Smaller hippocampal volume has repeatedly been reported in schizophrenia patients. Obstetric complications (OCs) and single nucleotide polymorphism (SNP) variation in schizophrenia susceptibility genes have independently been related to hippocampal volume. We investigated putative independent and interaction effects of severe hypoxia-related OCs and variation in four hypoxia-regulated schizophrenia susceptibility genes (BDNF, DTNBP1, GRM3 and NRG1) on hippocampal volume in schizophrenia patients and healthy controls. Clinical assessment, structural MRI scans, and blood samples for genotyping of 32 SNPs were obtained from 54 schizophrenia patients and 53 control subjects. Information on obstetric complications was collected from original birth records. Severe OCs were related to hippocampal volume in both patients with schizophrenia and healthy control subjects. Of the 32 SNPs studied, effects of severe OCs on hippocampal volume were associated with allele variation in GRM3 rs13242038, but the interaction effect was not specific for schizophrenia. SNP variation in any of the four investigated genes alone did not significantly affect hippocampal volume. The findings suggest a gene-environment (G x E) interaction between GRM3 gene...Continue Reading

References

Jan 1, 1993·The Journal of Neuropsychiatry and Clinical Neurosciences·N C AndreasenW T Yuh
May 11, 2000·Analytical Biochemistry·A AhmadianJ Lundeberg
Oct 3, 2000·Development and Psychopathology·S Marenco, D R Weinberger
Nov 2, 2001·The British Journal of Psychiatry : the Journal of Mental Science·C DalmanP Allebeck
Mar 8, 2002·European Archives of Psychiatry and Clinical Neuroscience·I AgartzG Sedvall
Jul 2, 2002·The American Journal of Psychiatry·Mary CannonRobin M Murray
Nov 20, 2002·Journal of Neurochemistry·Vemuganti L Raghavendra RaoRobert J Dempsey
Nov 29, 2002·American Journal of Medical Genetics·Hélène Verdoux, Anne-Laure Sutter
Apr 6, 2004·Brain Research. Brain Research Reviews·Patricia Boksa
Sep 4, 2004·Human Molecular Genetics·Tadahiro NumakawaRyota Hashimoto
May 27, 2005·PLoS Medicine·Sukanta SahaJohn McGrath
Jun 11, 2005·Bioinformatics·Janis E Wigginton, Gonçalo R Abecasis
Aug 19, 2005·Early Human Development·Sandra Rees, Terrie Inder
Dec 1, 2005·Nordic Journal of Psychiatry·Birgit EkholmErik G Jönsson
Dec 7, 2005·The American Journal of Psychiatry·Robyn HoneaClare E Mackay
Apr 4, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Erik G JönssonLars Terenius
Apr 25, 2006·Schizophrenia Research·Rainald Schmidt-KastnerChristoph Schmitz
May 23, 2006·Gene Expression Patterns : GEP·M J WebsterC Shannon Weickert
Jun 3, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ingrid AgartzErik G Jönsson
Aug 7, 2007·Neuropharmacology·Daniela MelchiorriFerdinando Nicoletti
Nov 6, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Sandra ReesDavid Walker
Mar 12, 2008·Current Opinion in Psychiatry·Neeltje E van HarenRené S Kahn
Jun 3, 2008·Schizophrenia Research·Rajiv TandonHenry A Nasrallah
Jul 29, 2008·Schizophrenia Research·Florian EbnerPeter Falkai
Oct 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Romain H FontaineOlivier Baud
Mar 28, 2009·Schizophrenia Bulletin·Oliver D Howes, Shitij Kapur
May 29, 2009·Journal of Psychiatric Research·Unn Kristin HaukvikIngrid Agartz

❮ Previous
Next ❯

Citations

Aug 26, 2011·European Archives of Psychiatry and Clinical Neuroscience·Andrea SchmittPeter Falkai
Oct 26, 2013·Journal of Psychiatric Research·Magdalena Kotlicka-AntczakTomasz Pawełczyk
Apr 25, 2013·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Unn Kristin HaukvikIngrid Agartz
Oct 30, 2015·Progress in Neurobiology·Yavuz AyhanMikhail V Pletnikov
Sep 10, 2015·Psychiatry Research·Asko WegeliusWilliam Hennah
Jun 21, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Kristy R Howell, Anilkumar Pillai
Jun 5, 2012·Psychiatry Research·Maria EkerholmHåkan Nyman
Jul 5, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Tomas HajekCyril Höschl
Nov 3, 2012·Schizophrenia Research·Shana Golembo-SmithJason Schiffman
May 9, 2014·Frontiers in Human Neuroscience·Jenny Gu, Ryota Kanai
Jun 11, 2016·Neuroscience and Biobehavioral Reviews·Md Shaki MostaidChad A Bousman
Aug 9, 2017·Translational Psychiatry·S M SainiC A Bousman
Dec 1, 2021·Inquiry : a Journal of Medical Care Organization, Provision and Financing·Lina Díaz-CastroMiguel Ángel Herrera-Estrella

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Polyendocrinopathies

Autoimmune polyendocrinopathies, also called polyglandular autoimmune syndromes (PGASs), or polyendocrine autoimmune syndromes(PASs), are a heterogeneous group of rare diseases characterized by autoimmune activity against more than one endocrine organ, although non-endocrine organs can be affected. Discover the latest research on autoimmune polyendocrinopathies here.

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.