An exploratory study into the role of dynamic contrast-enhanced (DCE) MRI metrics as predictors of response in head and neck cancers

Clinical Radiology
S AgrawalRam K S Rathore

Abstract

To assess the efficacy of dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) in prediction of the response to treatment in patients with head and neck cancers (HNCs). Twenty-one patients with advanced HNC, suitable for concurrent chemoradiotherapy underwent DCE MRI, for the quantification of blood flow (BF) and volume (BV). All the patients received radical doses of conventionally fractionated radiotherapy up to a dose of 70 Gy along with concurrent weekly cisplatin. The values of BV and BF were higher in complete responders as compared to partial responders at primary as well as nodes. Both BF and BV were found to be significantly higher in patients with high T-stage as compared to patients with lower T-stage. DCE metrics can be used as a predictor of response to treatment in locally advanced HNCs after validation of these observations in a larger number of patients.

References

Jul 1, 1999·International Journal of Radiation Oncology, Biology, Physics·P StadlerM Molls
Oct 18, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M Nordsmark, J Overgaard
Dec 11, 2002·The Lancet Oncology·Johannes H A M KaandersAlbert J van der Kogel
Nov 25, 2003·International Journal of Radiation Oncology, Biology, Physics·Robert HermansPhilippe Lambin
Jun 3, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Francesca M BuffaGeorge D Wilson
Jul 6, 2004·International Journal of Radiation Oncology, Biology, Physics·Kaisa LehtiöHeikki Minn
Dec 2, 2004·The British Journal of Radiology·A Jackson
Jun 1, 2007·Journal of Computer Assisted Tomography·Rakesh K GuptaRam Kishore S Rathore
Dec 20, 2008·Journal of Magnetic Resonance Imaging : JMRI·Anup SinghRakesh K Gupta

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Citations

Nov 15, 2013·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Priya BhatnagarAndrew F Scarsbrook
Dec 5, 2014·Medical Physics·Fahmi KhalifaAmy C Dwyer
Oct 3, 2015·AJNR. American Journal of Neuroradiology·S GaddikeriY Anzai
Jun 28, 2014·Medical Image Analysis·Nikolaos DikaiosDavid Atkinson
Feb 25, 2015·Atlas of the Oral and Maxillofacial Surgery Clinics of North America·John N St J BlythePeter A Brennan
Nov 7, 2018·The Neuroradiology Journal·Ahmed H El BeltagiSurjith Vattoth

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