PMID: 8973130Oct 1, 1996Paper

An exploratory study of frequent pain measurement in a cancer clinical trial

Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation
J InghamR Portenoy

Abstract

The ideal methodology for quality of life (QOL) measurement in cancer clinical trials matches the evaluation to the anticipated outcomes, thereby increasing the likelihood that clinically relevant changes are captured. The present study explored the importance of such methodological 'tailoring' in a phase II trial of paclitaxel and recombinant human granulocyte-colony stimulating factor (rhG-CSF) for metastatic breast cancer. Prior to the trial, clinical observation suggested that frequent short-lived episodes of pain might occur during this treatment regimen. Twenty-one patients provided longitudinal data for at least three cycles of chemotherapy. To assess transient pain, a routine QOL assessment at baseline and every third cycle was supplemented with pain measurements twice weekly. The interval assessment included a multidimensional QOL instrument (Functional Living Index-Cancer) and measures of psychological state (Rand Mental Health Inventory), symptom distress (Memorial Symptom Assessment Scale), and performance status (Karnofsky Performance Status Score). The frequent pain measurements were acquired using visual analogue and categorical scales for pain intensity (Memorial Pain Assessment Card). From baseline to the end o...Continue Reading

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Citations

Aug 30, 2000·Cancer·V T ChangH T Thaler
Jun 18, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Yolanda EscobarFrancisco Valcárcel
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Aug 24, 2010·Journal of Psychosocial Oncology·Ruvanee P VilhauerAlicia K Matthews
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May 4, 2004·Journal of Pain and Symptom Management·Augusto CaraceniFranco De Conno
Aug 28, 2014·Palliative & Supportive Care·Lilian Hennemann-KrauseRodolfo Acatauassú Nunes
Dec 5, 2015·Mediators of Inflammation·Carolina Panis, Wander Rogério Pavanelli
Mar 11, 2005·Oncology Nursing Forum·Teresa T Goodell, Lillian M Nail

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