An exploratory study to assess the activity of the acarine growth inhibitor, fluazuron, against Sarcoptes scabei infestation in pigs.

Parasites & Vectors
Cielo PasayJames McCarthy

Abstract

The most common treatments for scabies in human and veterinary settings are topical 5% permethrin or systemic treatment with ivermectin. However, these treatments have very little activity against arthropod eggs, and therefore repeated treatment is frequently required. In-vitro, biochemical and molecular studies have demonstrated that human mites are becoming increasingly resistant to both acaricides. To identify alternate acaricides, we undertook a pilot study of the in vivo activity of the benzoylphenyl urea inhibitor of chitin synthesis, fluazuron, in pigs with sarcoptic mange. Pigs (n = 5) were infested with S. scabei var suis, and randomised to treatment at the start of peak infestation with fluazuron at a dose of 10 mg/kg/day per os for 7 days (n = 3) or no treatment (n = 2). Clinical scores, skin scrapings for mite counts and blood sampling for pharmacokinetic analysis were undertaken. Fluazuron was well absorbed in treated pigs with measureable blood levels up to 4 weeks post treatment. No adverse effects were observed. Modest acaricidal activity of the compound was observed, with a reduction in severity of skin lesions in treated pigs, as well as a reduction in number of scabies mite's early life stages. The moderate e...Continue Reading

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Aug 17, 2010·PloS One·Cielo PasayJames McCarthy

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Citations

Aug 18, 2012·Parasites & Vectors·Runhui ZhangGuangyou Yang
Aug 22, 2012·The Journal of Dermatological Treatment·Mohamad GoldustRamin Raghifar
Oct 24, 2012·Trends in Parasitology·Kate E MounseyShelley F Walton
Dec 1, 2017·PLoS Neglected Tropical Diseases·Samar KhalilMazen Kurban
May 2, 2019·Parasite : Journal De La Société Française De Parasitologie·Pablo JunqueraAlicia Macdonald
Sep 19, 2019·Infection Ecology & Epidemiology·Thang Nguyen-TienJohanna Lindahl
Feb 27, 2013·Current Opinion in Infectious Diseases·Kate E Mounsey, James S McCarthy
Apr 18, 2018·International Journal of Dermatology·Hima GopinathKaliaperumal Karthikeyan
Nov 28, 2020·Future Medicinal Chemistry·Wali InamWajahat Mahmood
Dec 14, 2018·Dermatology : International Journal for Clinical and Investigative Dermatology·David J Chandler, Lucinda C Fuller

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Methods Mentioned

BETA
scrapings

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