PMID: 2507678Aug 1, 1989Paper

An expression of squamous cell carcinoma-related antigen in oral cancers

International Journal of Oral and Maxillofacial Surgery
T TsujiF Shinozaki

Abstract

The relationship between serum level and stainability of squamous cell carcinoma-related antigen (SCC-Ag) in carcinoma of the oral cavity was examined. The amount of serum SCC-Ag was measured in 60 of 97 patients by a radioimmunoassay system. 63.3% showed elevated serum SCC-Ag levels above 2.0 ng/ml. The specimens taken from 97 patients with oral squamous cell carcinoma (SCC) were stained with a monoclonal antibody against the SCC-Ag by using an immunoperoxidase method. Tumor cells with keratinization in well-differentiated SCC stained well with the antibody, whereas cells without keratinization in poorly-differentiated SCC stained weakly, or not at all. Serum levels of the antigen were significantly higher in cases of invasive cancers, but serum levels of antigen correlated with neither the degree of morphological differentiation of the tumor, nor with the intracellular content of the antigen. These observations suggest that the parenchymalstromal relationship is one of the decisive factors in determining the serum SCC-Ag level.

References

Jan 1, 1984·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·G UedaY Abe

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Citations

Nov 1, 1991·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·L M Lin, Y K Chen
Jul 1, 1993·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·C Scully, A Burkhardt
Aug 1, 1995·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Y K Chen, L M Lin
Jan 24, 2007·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Chung-Ho ChenChi-Cheng Tsai
Jun 11, 2017·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Daphine Caxias TravassosAndreia Bufalino
Feb 1, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S CataltepeM P Upton
Feb 15, 2021·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yu-Hsueh WuYang-Che Wu
Jun 19, 2021·Journal of Dental Sciences·Yu-Hsueh WuChun-Pin Chiang

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