An extended bidomain framework incorporating multiple cell types.

Biophysical Journal
Martin L Buist, Yong Cheng Poh

Abstract

The muscular layers within the walls of the gastrointestinal tract contain two distinct cell types, the interstitial cells of Cajal and smooth muscle cells, which together produce rhythmic depolarizations known as slow waves. The bidomain model of tissue-level electrical activity consists of single intracellular and extracellular domains separated by an intervening membrane at all points in space and is therefore unable to adequately describe the presence of two distinct cell types in its conventional form. Here, an extension to the bidomain framework is presented whereby multiple interconnected cell types can be incorporated. Although the derivation is focused on the interactions of the interstitial cells of Cajal and smooth muscle cells, the conceptual framework can be more generally applied. Simulations demonstrating the feasibility of the proposed model are also presented.

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Citations

Feb 10, 2012·Pancreas·Mihnea I Nicolescu, Laurentiu M Popescu
Sep 1, 2011·IEEE Transactions on Bio-medical Engineering·Peng DuLeo K Cheng
Jun 17, 2015·IEEE Transactions on Bio-medical Engineering·Shameer SatharLeo K Cheng
Nov 4, 2010·Biophysical Journal·Peng DuAndrew J Pullan
Oct 1, 2011·Journal of Theoretical Biology·Yong Cheng PohMartin L Buist
Jan 10, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Alberto CorriasMartin L Buist
Jan 31, 2018·Frontiers in Physiology·Peng DuLeo K Cheng
Sep 19, 2019·Biomechanics and Modeling in Mechanobiology·Thomas KlotzOliver Röhrle
Mar 7, 2013·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Peng DuLeo K Cheng
Dec 17, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sean P Parsons, Jan D Huizinga
Oct 7, 2018·Bulletin of Mathematical Biology·Louise A BowlerJonathan P Whiteley

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