An extended cost-effectiveness analysis of publicly financed HPV vaccination to prevent cervical cancer in China

Vaccine
Carol LevinJane J Kim

Abstract

Cervical cancer screening and existing health insurance schemes in China fall short of reaching women with prevention and treatment services, especially in rural areas where the disease burden is greatest. We conducted an extended cost-effectiveness analysis (ECEA) to evaluate public financing of HPV vaccination to prevent cervical cancer, adding new dimensions to conventional cost-effectiveness analysis through an explicit inclusion of equity and impact on financial risk protection. We synthesized available epidemiological, clinical, and economic data from China using an individual-based Monte Carlo simulation model of cervical cancer to estimate the distribution of deaths averted by income quintile, comparing vaccination plus screening against current practice. We also estimated reductions in cervical cancer incidence, net costs to the government (HPV vaccination costs minus cervical cancer treatment costs averted), and patient cost savings, as well as the incremental government health care costs per death averted. HPV vaccination is cost-effective across all income groups when the cost is less than US $50 per vaccinated girl. Compared to screening alone, adding preadolescent HPV vaccination followed by cervical cancer screen...Continue Reading

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Citations

Dec 7, 2017·Health Care for Women International·Ha Dinh ThuAnne Buvé
Sep 13, 2017·Australian and New Zealand Journal of Public Health·Anita LalRob Carter
Oct 7, 2017·Singapore Medical Journal·Sun Kuie TayGeorges Van Kriekinge
Apr 25, 2019·Human Vaccines & Immunotherapeutics·Li Ping WongGregory D Zimet
May 21, 2020·International Journal of Environmental Research and Public Health·Viju RaghupathiWullianallur Raghupathi
Jun 28, 2018·BMC Medical Ethics·Marium Salwa, Tarek Abdullah Al-Munim
Jul 28, 2020·International Journal of Public Health·Saba AbidiPuneeta Ajmera
Jan 16, 2020·International Journal for Equity in Health·Allison PortnoyMark Jit
Sep 30, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F IslamiA Jemal

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