An Extended Cyclic Di-GMP Network in the Predatory Bacterium Bdellovibrio bacteriovorus

Journal of Bacteriology
Or RotemEdouard Jurkevitch

Abstract

Over the course of the last 3 decades the role of the second messenger cyclic di-GMP (c-di-GMP) as a master regulator of bacterial physiology was determined. Although the control over c-di-GMP levels via synthesis and breakdown and the allosteric regulation of c-di-GMP over receptor proteins (effectors) and riboswitches have been extensively studied, relatively few effectors have been identified and most are of unknown functions. The obligate predatory bacterium Bdellovibrio bacteriovorus has a peculiar dimorphic life cycle, in which a phenotypic transition from a free-living attack phase (AP) to a sessile, intracellular predatory growth phase (GP) is tightly regulated by specific c-di-GMP diguanylate cyclases. B. bacteriovorus also bears one of the largest complement of defined effectors, almost none of known functions, suggesting that additional proteins may be involved in c-di-GMP signaling. In order to uncover novel c-di-GMP effectors, a c-di-GMP capture-compound mass-spectroscopy experiment was performed on wild-type AP and host-independent (HI) mutant cultures, the latter serving as a proxy for wild-type GP cells. Eighty-four proteins were identified as candidate c-di-GMP binders. Of these proteins, 65 did not include any...Continue Reading

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Citations

Sep 1, 2016·Nature Communications·Yu-Chuan WangShan-Ho Chou
Feb 7, 2017·Nature Reviews. Microbiology·Urs JenalChristian Lori
Mar 30, 2017·Biophysical Journal·Hossein JashnsazSteve Pressé
Aug 16, 2017·Physical Biology·Hossein JashnsazSteve Pressé
May 19, 2019·Molecular Microbiology·Ronan R McCarthyAlain Filloux
Mar 27, 2020·Environmental Microbiology Reports·Lara RajeevAindrila Mukhopadhyay
Jun 15, 2017·Médecine sciences : M/S·Édouard Jurkevitch, Stéphan Jacquet

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