An extension to the compartmental model of type 1 diabetic patients to reproduce exercise periods with glycogen depletion and replenishment

Journal of Biomechanics
M Hernández-Ordoñez, D U Campos-Delgado

Abstract

The purpose of this work is to present the main interactions promoted by exercise and synthesize them into mathematical equations. It is intended to extend the ability of the compartmental glucose-insulin model introduced by Sorensen [1985. A physiologic model of glucose metabolism in man and its use to design and assess improved insulin therapies for diabetes. Ph.D. Dissertation, Chemical Engineering Department, MIT, Cambridge] to reproduce variations in the blood glucose concentration induced by exercise in diabetic patients and to complement the previous work by Lenart and Parker [2002. Modeling exercise effects in type I diabetic patients. In: Proceedings of the 15th Triennial World Congress, Barcelona, Spain] and Lenart, DiMascio and Parker [2002. Modeling glycogen-exercise interactions in type I diabetic patients. In: Proceedings of the A.I.Ch.E. Annual Meeting, Indianapolis, IN]. The immediate consequences of exercise are incorporated in this research: redistribution of blood flows, increments in peripheral glucose and insulin uptakes, and increment in hepatic glucose production. The extended model was verified with experimental data for light and moderate intensity exercise. In addition, data extrapolation was introduce...Continue Reading

References

Dec 1, 1971·The Journal of Clinical Investigation·J WahrenL Jorfeldt
Sep 7, 2001·Diabetes/metabolism Research and Reviews·J Radziuk, S Pye
Jun 8, 2002·Journal of Biomechanics·M Derouich, A Boutayeb
May 1, 1965·Scientific American·C B CHAPMAN, J H MITCHELL
Nov 1, 2006·IEEE Transactions on Bio-medical Engineering·D U Campos-DelgadoA Gordillo-Moscoso

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Oct 24, 2015·Medical & Biological Engineering & Computing·O VahidiF K Knop
Feb 5, 2014·Statistical Methods in Medical Research·Sean M EwingsAndrew J Chipperfield
Jun 11, 2020·Sensors·Nichole S Tyler, Peter G Jacobs

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