An extensive network of coupling among gene expression machines

Nature
Tom Maniatis, Robin Reed

Abstract

Gene expression in eukaryotes requires several multi-component cellular machines. Each machine carries out a separate step in the gene expression pathway, which includes transcription, several pre-messenger RNA processing steps and the export of mature mRNA to the cytoplasm. Recent studies lead to the view that, in contrast to a simple linear assembly line, a complex and extensively coupled network has evolved to coordinate the activities of the gene expression machines. The extensive coupling is consistent with a model in which the machines are tethered to each other to form 'gene expression factories' that maximize the efficiency and specificity of each step in gene expression.

References

Mar 1, 1989·Trends in Biochemical Sciences·N J Proudfoot
Feb 10, 1995·The Journal of Biological Chemistry·S M Berget
Aug 9, 1996·The Journal of Biological Chemistry·M E Dahmus
May 29, 1997·Nature·T MisteliD L Spector
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·P CramerA R Kornblihtt
Dec 16, 1997·Trends in Biochemical Sciences·J L Corden, M Patturajan
Apr 18, 1998·The Journal of Biological Chemistry·S TrigonM Morange
Dec 5, 1998·Nucleic Acids Research·G C RobertsC W Smith
Jan 16, 1999·Current Biology : CB·B R GraveleyT Maniatis
Feb 20, 1999·Cell·M W Hentze, A E Kulozik
May 18, 1999·The EMBO Journal·N CustódioM Antoniou
Jun 29, 1999·Cold Spring Harbor Symposia on Quantitative Biology·S McCrackenD Bentley
Jul 8, 1999·Current Opinion in Cell Biology·D Bentley
Jul 27, 1999·Genes & Development·Y Wen, A J Shatkin
Aug 10, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K CzaplinskiS W Peltz
Aug 24, 1999·Molecular and Cellular Biology·J B KimP A Sharp
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·M J Luo, R Reed
Mar 25, 2000·Molecular and Cellular Biology·D H Price
Apr 15, 2000·Nature·R D Phair, T Misteli
May 10, 2000·Current Opinion in Cell Biology·R Reed
Jun 6, 2000·Trends in Biochemical Sciences·N Proudfoot
Sep 9, 2000·The Journal of Biological Chemistry·D P Morris, A L Greenleaf

❮ Previous
Next ❯

Citations

Jul 17, 2008·Comparative and Functional Genomics·Thomas Schlitt, Alvis Brazma
Nov 1, 2002·Reviews in Medical Virology·David E Ott
Nov 29, 2007·Cellular and Molecular Life Sciences : CMLS·R E HalbeisenA P Gerber
Dec 26, 2007·Cellular and Molecular Life Sciences : CMLS·C R MandelL Tong
Dec 14, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Julian C Knight
Jun 20, 2008·Chromosoma·Manfred Schmid, Torben Heick Jensen
May 4, 2007·Molecular Genetics and Genomics : MGG·Kellie E BarbaraGeorge M Santangelo
Jul 16, 2010·Human Genetics·Jana Kralovicova, Igor Vorechovsky
Sep 22, 2010·Medical Molecular Morphology·Tominori KimuraHisao Yamada
Jul 19, 2012·In Vitro Cellular & Developmental Biology. Animal·Jian-Guo HuangXin Jin
Mar 10, 2011·Molecular Biotechnology·Natasa SkokoEmanuele Buratti
Aug 14, 2013·Journal of Biosciences·Satarupa Das, Biswadip Das
Jun 11, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Maria MontiPiero Pucci
Jun 7, 2005·Cellular Signalling·Pascal LoyerJill M Lahti
Nov 5, 2013·Cell Reports·Isabel X WangVivian G Cheung
Mar 31, 2005·Trends in Genetics : TIG·Kenneth E M Hastings
Apr 9, 2005·Experimental Cell Research·Guohua ZhaoPeter N Kao
Jul 24, 2002·Biochemical and Biophysical Research Communications·Claudio R AlonsoAlberto R Kornblihtt
Dec 4, 2002·Journal of Molecular Biology·Silke WiesnerMaria J Macias
Dec 11, 2002·Current Opinion in Cell Biology·Francisco J Iborra, Peter R Cook
Jun 6, 2003·Current Opinion in Cell Biology·Dean A Jackson
Jun 6, 2003·Current Opinion in Cell Biology·Robin Reed
Nov 16, 2002·Current Opinion in Genetics & Development·Michael Lynch, Aaron O Richardson
Apr 4, 2003·Current Opinion in Genetics & Development·Grant A Hartzog
Jan 9, 2003·Trends in Biochemical Sciences·Ana Pombo
Apr 26, 2003·Trends in Biochemical Sciences·Hervé Le HirMelissa J Moore
Aug 23, 2003·Trends in Biochemical Sciences·Bryan R Cullen
Dec 20, 2002·Journal of Structural Biology·Lindsay S ShoplandJeanne B Lawrence
Dec 20, 2002·Journal of Structural Biology·Olivier Gadal, Ulf Nehrbass
Dec 20, 2002·Journal of Structural Biology·Christine K DregerHarald Herrmann
Jan 28, 2003·Current Opinion in Chemical Biology·Anne-Claude Gavin, Giulio Superti-Furga
Dec 17, 2002·Current Opinion in Pharmacology·Michael Norman, Stephen D Hearing
Oct 31, 2002·RNA·Rui PengJames G Patton
Oct 23, 2008·Bioconjugate Chemistry·Nitin Nitin, Gang Bao
Apr 20, 2013·Chemical Reviews·Argyris Papantonis, Peter R Cook
Jul 12, 2002·Nature·Tom Maniatis, Bosiljka Tasic
Sep 13, 2002·Nature·Zhaolan ZhouRobin Reed
Jul 1, 2005·Nature·Tae Hoon KimBing Ren
Nov 4, 2008·Nature·Donny D LicatalosiRobert B Darnell
Nov 4, 2008·Nature·Eric T WangChristopher B Burge

❮ Previous
Next ❯

Related Concepts

Related Feeds

CZI Human Cell Atlas Seed Network

The aim of the Human Cell Atlas (HCA) is to build reference maps of all human cells in order to enhance our understanding of health and disease. The Seed Networks for the HCA project aims to bring together collaborators with different areas of expertise in order to facilitate the development of the HCA. Find the latest research from members of the HCA Seed Networks here.