PMID: 9420648Mar 1, 1995Paper

An extra-adrenal sodium-retaining factor in congestive heart failure

Journal of Cardiac Failure
J O Davis

Abstract

The extra-adrenal sodium-retaining factor was first described in Circulation Research in 1964. This factor increases the responsiveness of the renal tubules to aldosterone in heart failure, and marked sodium retention occurs with resultant edema or ascites. Evidence for the extra-adrenal sodium-retaining factor is presented in two models of experimental heart failure in dogs and in dogs with thoracic caval constriction and a low cardiac output. Since the nature of this sodium-retaining factor remains unknown, several of the recently discovered factors that influence kidney function and that might alter the responsiveness of the renal tubules to a mineralocorticoid are described. These factors include atrial natriuretic peptide, nitric oxide, 11 beta-hydroxysteroid dehydrogenase activity, the endothelins, and the intrarenal tissue renin-angiotensin system. It is suggested that the nature and action of the sodium-retaining factor be reinvestigated in lieu of the new knowledge of kidney function. The applicability of newly developed experimental models of heart failure for study of the extra-adrenal factor is discussed; these include coronary artery ligation in rats, cardiac pacing in the dog, and application of transmyocardial di...Continue Reading

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·C S WilcoxH H Schmidt
Mar 1, 1992·Hypertension·J D Horisberger, B C Rossier
Apr 1, 1992·Clinical and Experimental Pharmacology & Physiology·P J Harris
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Feb 1, 1984·The Journal of Clinical Investigation·V L SchusterH R Jacobson

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Citations

Aug 15, 1996·The New England Journal of Medicine·J N Cohn
Jul 14, 1999·Current Problems in Cardiology·P E Carson

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