PMID: 3773648Nov 17, 1986Paper

An extract of rat submandibular glands activates platelets and enhances cutaneous vascular permeability in rats and guinea pigs

Life Sciences
C P CoxK L Wood

Abstract

Washed, [3H]serotonin-labeled platelets from rats and guinea pigs were stimulated in vitro with a novel protein extracted from rat submandibular salivary glands (RS-PAP) and with the phospholipid platelet- activating factor 1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine (AGEPC). Rat platelets, which are refractory to AGEPC stimulation, underwent shape-change, aggregation and secretion of [3H]serotonin in response to graded doses of RS-PAP and AGEPC. Intradermal injections of histamine, RS-PAP and AGEPC caused a dose-related increase in local microvascular permeability in rats, as measured by the extravasation of plasma containing Evans blue dye. Similarly, histamine, RS-PAP and AGEPC increased cutaneous vascular permeability when injected intradermally in guinea pigs. The vascular permeability induced by histamine and RS-PAP, but not by AGEPC, was partially inhibited by pretreatment with an antihistamine (diphenhydramine HCl). Pretreatment of guinea pigs with captopril, an inhibitor of angiotensin-converting enzyme (ACE), partially inhibited cutaneous responses to subsequent intradermal injections of histamine, RS-PAP and AGEPC. Regardless of pretreatment with diphenhydramine or captopril, skin test sites injected with large...Continue Reading

References

Nov 1, 1978·Thrombosis Research·F SantosR H Wagner
Mar 25, 1975·Biochemistry·B M MartinT C Detwiler
Mar 1, 1985·Inflammation·B GerdinG Smedegøard
Jun 1, 1982·The Journal of Clinical Investigation·J C FantoneB Weingarten
Oct 14, 1983·Journal of Immunological Methods·J H WellsW A Cain
Aug 1, 1980·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T Barka

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