PMID: 7370485Feb 1, 1980Paper

An extrapyramidal syndrome after lithium therapy

The British Journal of Psychiatry : the Journal of Mental Science
P TyrerI Lee

Abstract

Two patients developed an extrapyramidal syndrome after therapy with lithium carbonate. Although the clinical features of this syndrome were indistinguishable from those of drug-induced parkinsonism, it was made worse by the anti-parkinsonian drug, orphenadrine. These findings were reproduced later under laboratory conditions when extrapyramidal symptoms and physiological tremor were recorded before and after challenge doses of orphenadrine. This unwanted effect of lithium carbonate may be explained by selective blockade of dopamine receptors.

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Citations

May 1, 1983·Journal of Affective Disorders·A PerényiC M Bánki
Jan 1, 1994·Fundamental & Clinical Pharmacology·J L MontastrucJ M Senard
Jan 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·S J Smith, R S Kocen
Jul 29, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yu-Chi HuangPao-Yen Lin
Jun 16, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Emmanuelle Bondon-GuittonJean-Louis Montastruc
Jun 22, 2002·International Journal of Psychiatry in Medicine·Chanoch MiodownikVladimir Lerner
Dec 1, 1996·The Australian and New Zealand Journal of Psychiatry·D K Arya
Jul 14, 2001·The British Journal of Psychiatry. Supplement·J Cookson
Jul 1, 1981·The British Journal of Psychiatry : the Journal of Mental Science·P TyrerC Trotter
Jan 1, 1983·The British Journal of Psychiatry : the Journal of Mental Science·A J McGennis
Jul 1, 1983·The British Journal of Psychiatry : the Journal of Mental Science·S Pullinger, P Tyrer

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