An H2 S-sensing/CO-releasing Flavonol that Operates via Logic Gates

ChemPlusChem
Tatiana SobolevaLisa M Berreau

Abstract

Signaling molecules, including H2S and CO, are involved in a complex interplay within cells to maintain cellular homeostasis. In order to investigate the intracellular interplay of different gasotransmitters, new molecular tools are needed that combine sensing and release capabilities of different small molecules in a single, multifunctional, and highly-regulated molecular platform. This report gives the first example of a combined H2S sensor/CO-releasing molecule. This flavonol-based molecular tool operates intracellularly via a highly regulated AND logic gated input-output sequence and provides fluorescent feedback for the H2S detection and CO release steps. This linear sequence can be combined with a fluorescent molecular sensor for CO detection via a third distinct emission. Overall, this is the first molecular framework that can combine the sensing of H2S with the controlled release of CO, two gaseous molecules that are known to exhibit reciprocal regulation and have overlapping targets in cellular environments.

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Citations

Apr 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tatiana Soboleva, Lisa M Berreau
Aug 11, 2020·Macromolecular Rapid Communications·Mingyang ZhangRuirui Qiao
May 26, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Tomáš Slanina, Peter Šebej
Sep 14, 2019·Israel Journal of Chemistry·Tatiana Soboleva, Lisa M Berreau
Sep 10, 2020·Angewandte Chemie·Siyue TaoJinming Hu
Sep 16, 2020·Accounts of Chemical Research·Livia S LazarusLisa M Berreau
Oct 31, 2020·Chemical Reviews·Roy WeinstainPetr Klán
Sep 10, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ying-Ji Sun, Chao Yu

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