PMID: 9430248Jan 16, 1998Paper

An HIV type 2 DNA vaccine induces cross-reactive immune responses against HIV type 2 and SIV

AIDS Research and Human Retroviruses
Michael G AgadjanyanD B Weiner

Abstract

We have previously reported on the generation of specific functional immune responses after inoculation of animals with expression vectors encoding HIV-1 genes. This article provides the details of the first application of this new technology to induce immune responses against HIV-2. This virus is molecularly and serologically distinct from HIV-1 and is in fact more closely related to the simian immunodeficiency virus (SIV). Anti-HIV-2 and SIV antibodies were induced in mice of three different haplotypes following a single intramuscular inoculation with an HIV-2/ROD envelope glycoprotein expression vector (pcEnv-2). Boosting of animals with pcEnv-2 induced both anti-HIV-2 neutralizing antibodies and T cell-proliferative responses against HIV-2 and SIVmac proteins. We compared the humoral and cellular immune responses of mice injected with pcEnv-2 and then boosted with either the homologous DNA construct or a recombinant Env protein. Animals boosted with pcEnv-2 generated B and T cell immune responses as strong as those of mice boosted with recombinant gp140 protein in adjuvant. Finally, cellular immune responses were significantly increased with the coadministration of pcEnv-2 and a plasmid expressing interleukin 12. We therefo...Continue Reading

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Citations

Aug 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·X FornsJ Bukh
Jan 17, 2002·Viral Immunology·J M Smith, J V Torres
Feb 27, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J J KimD B Weiner
Jan 31, 2002·AIDS·P J Bock, D M Markovitz
Oct 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael G AgadjanyanDavid B Weiner
Jan 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael G AgadjanyanDavid H Cribbs

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