An IAP-IAP complex inhibits apoptosis.

The Journal of Biological Chemistry
Takehiko DohiDario C Altieri

Abstract

Regulators of apoptosis are thought to work in concert, but the molecular interactions of this process are not understood. Here, we show that in response to cell death stimulation, survivin, a member of the inhibitor of apoptosis (IAP) gene family, associates with another IAP protein, XIAP, via conserved baculovirus IAP repeats. Formation of a survivin-XIAP complex promotes increased XIAP stability against ubiquitination/proteasomal destruction and synergistic inhibition of apoptosis, which is abolished in XIAP(-/-) cells. Therefore, orchestration of an IAP-IAP complex regulates apoptosis.

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Citations

Nov 27, 2008·Cancer Chemotherapy and Pharmacology·Kate ConnollySylvie Guichard
Jun 19, 2007·Apoptosis : an International Journal on Programmed Cell Death·Allison M HunterRobert G Korneluk
Nov 18, 2010·Apoptosis : an International Journal on Programmed Cell Death·Hsien-Chia JuanFen-Hwa Wong
Jun 25, 2013·Cancer Letters·Rosalia de Necochea-CampionNathan R Wall
Sep 26, 2013·European Journal of Cell Biology·Gabriela Nestal de MoraesRaquel C Maia
Sep 3, 2013·Journal of Biotechnology·Varsha P Wadegaonkar, Prasad A Wadegaonkar
Oct 30, 2008·Journal of Medicinal Chemistry·Jui-Wen HuangMaurizio Pellecchia
Oct 19, 2012·Cell Death & Disease·K-S ChanH-Y Li
Sep 7, 2013·Cell Death & Disease·T K Oberoi-KhanujaK Rajalingam
Dec 14, 2007·Nature Reviews. Cancer·Dario C Altieri
Oct 22, 2008·Oncogene·E C LaCasseR G Korneluk
Oct 22, 2008·Oncogene·D C Altieri
May 4, 2011·The Journal of Biological Chemistry·Marat S PavlyukovMihail I Shakhparonov
Jul 3, 2008·Cancer Biotherapy & Radiopharmaceuticals·Tongbo YiZhengyan Wu
Feb 13, 2009·Molecular Biology of the Cell·Petra ObexerMichael Ausserlechner
Aug 22, 2009·Journal of Oncology·Daris FerrariPaolo Foa
Oct 19, 2004·The Journal of Clinical Investigation·Takehiko DohiDario C Altieri
Apr 12, 2007·BMC Biochemistry·Yuichi Tsuchiya, Shigeru Yamashita
Apr 8, 2011·Molecular Cancer·Ronan J KellyJohn C Morris

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