PMID: 8958931Oct 31, 1996Paper

An IL-12-based vaccine approach for preventing immunopathology in schistosomiasis

Annals of the New York Academy of Sciences
A SherT A Wynn

Abstract

Schistosomiasis is a major parasitic disease of developing countries. Pathology in schistosome infection is caused by the host granulomatous response to parasite eggs deposited in the tissues and the ensuing fibrosis. Previous work established that Th2 CD4+ cells play a major role in expanding granulomatous lesions and in fibrosis in murine models. We have used IL-12 both therapeutically to downmodulate this response and as an adjuvant with egg antigens to prevent pathology after subsequent parasite challenge. These effects appears to rely on the induction of IFN-gamma by the injected IL-12. Interestingly, while IL-12 treatment or vaccination downregulates most egg-specific Th2 cytokine responses, IL-10 production in vivo is enhanced. Because we have also shown that IL-12 can be used as an adjuvant to augment protective immunity against this helminth, it may be possible to design a combined parasite Ag/IL-12 vaccine which both limits infection and blocks the tissue pathology caused by eggs of worms escaping the resistance mechanisms evoked by immunization. At a more general level, our results demonstrate the potential of IL-12-based vaccine strategies to block Th2-dependent disease processes including allergy.

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Citations

Feb 5, 1999·European Journal of Immunology·B P ArulanandamD W Metzger
Dec 4, 1998·Springer Seminars in Immunopathology·B MüllerZ Yin
Apr 6, 2004·Advanced Drug Delivery Reviews·Grace MulcahyJ P Dalton
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May 5, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·D F Jelinek
Aug 10, 1999·Journal of Gastroenterology and Hepatology·D Li, S L Friedman
Dec 3, 1999·Immunological Reviews·R M MaizelsM Yazdanbakhsh
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Jun 27, 2008·Acta Tropica·Eliana A G ReisMitermayer G Reis
Jan 15, 1999·Critical Reviews in Biotechnology·B P MahonK H Mills
Sep 14, 2004·Immunological Reviews·Miguel J StadeckerJing Sun
Feb 11, 2014·Current Protocols in Immunology·Matthew S TuckerYung-San Liang
Mar 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·B P ArulanandamD W Metzger

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