An IL28B polymorphism determines treatment response of hepatitis C virus genotype 2 or 3 patients who do not achieve a rapid virologic response

Gastroenterology
Alessandra MangiaJohn G McHutchison

Abstract

Polymorphisms in the region of the interleukin (IL)-28B gene on chromosome 19 have been associated with peginterferon-alfa-induced clearance of genotype 1 hepatitis C virus (HCV); there are no data for patients with genotype 2 or 3 HCV. We evaluated the effects of IL-28B polymorphisms on response to treatment with peginterferon and ribavirin in a well-characterized cohort of genotype 2/3 patients. DNA was analyzed from 268 patients (Caucasian: genotype 2, 213; genotype 3, 55). Patients were randomly assigned to groups that received standard duration (24 wk; n = 68) or variable durations of therapy. Patients who received variable durations (VD) and had a rapid virologic response (RVR) were treated for 12 weeks (VD12; n = 122); those without an RVR were treated for 24 weeks (VD24; n = 78). IL-28B genotypes (rs12979860) were analyzed for association with treatment response. The frequencies of the IL-28B genotypes were as follows: CC, 37%; CT, 48%; and TT, 15%; 82% of patients with the CC genotype achieved a sustained virologic response (SVR), compared with 75% with the CT and 58% with the TT genotypes (P = .0046). Differences between IL-28B genotypes were greatest among patients who failed to attain RVR (VD24 SVR rates: CC, 87%; C...Continue Reading

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Citations

Mar 5, 2013·Immunogenetics·Jean-François GélinasNaglaa H Shoukry
Oct 30, 2012·Journal of Gastroenterology·Wan-Long Chuang, Ming-Lung Yu
May 29, 2013·The Journal of Experimental Medicine·Stéphanie BibertUNKNOWN Swiss Hepatitis C Cohort Study
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Jun 1, 2012·Expert Review of Gastroenterology & Hepatology·Necati Örmeci, Hakan Erdem

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