An image-based model of brain volume biomarker changes in Huntington's disease.

Annals of Clinical and Translational Neurology
Peter A WijeratneDaniel C Alexander

Abstract

Determining the sequence in which Huntington's disease biomarkers become abnormal can provide important insights into the disease progression and a quantitative tool for patient stratification. Here, we construct and present a uniquely fine-grained model of temporal progression of Huntington's disease from premanifest through to manifest stages. We employ a probabilistic event-based model to determine the sequence of appearance of atrophy in brain volumes, learned from structural MRI in the Track-HD study, as well as to estimate the uncertainty in the ordering. We use longitudinal and phenotypic data to demonstrate the utility of the patient staging system that the resulting model provides. The model recovers the following order of detectable changes in brain region volumes: putamen, caudate, pallidum, insula white matter, nonventricular cerebrospinal fluid, amygdala, optic chiasm, third ventricle, posterior insula, and basal forebrain. This ordering is mostly preserved even under cross-validation of the uncertainty in the event sequence. Longitudinal analysis performed using 6 years of follow-up data from baseline confirms efficacy of the model, as subjects consistently move to later stages with time, and significant correlati...Continue Reading

References

Mar 1, 1996·Movement Disorders : Official Journal of the Movement Disorder Society
Mar 18, 2004·Clinical Genetics·D R LangbehnUNKNOWN International Huntington's Disease Collaborative Group
Aug 23, 2005·Biological Psychiatry·Jane S PaulsenPeg C Nopoulos
Mar 31, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Mark MühlauAlexander Peinemann
Dec 22, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·J S PaulsenUNKNOWN Predict-HD Investigators and Coordinators of the Huntington Study Group
Jan 20, 2010·Lancet Neurology·Clifford R JackJohn Q Trojanowski
Apr 14, 2010·Brain Research Bulletin·Jane S PaulsenUNKNOWN PREDICT-HD Investigators and Coordinators of the Huntington's Study Group (HSG)
Oct 5, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Elizabeth H AylwardUNKNOWN PREDICT-HD Investigators and Coordinators of Huntington Study Group
Jun 1, 2011·Journal of the Neurological Sciences·S J A van den BogaardR A C Roos
Jul 30, 2011·Journal of Alzheimer's Disease : JAD·Jussi MattilaUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Aug 23, 2011·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ying ZhangUNKNOWN PREDICT-HD Investigators and Coordinators of the Huntington Study Group
Aug 24, 2011·Current Neurology and Neuroscience Reports·Jane S Paulsen
Jul 13, 2012·The New England Journal of Medicine·Randall J BatemanUNKNOWN Dominantly Inherited Alzheimer Network
Feb 5, 2013·Neuroscience and Biobehavioral Reviews·Nellie Georgiou-KaristianisElizabeth Aylward
Mar 13, 2013·Lancet Neurology·Victor L VillemagneUNKNOWN Australian Imaging Biomarkers and Lifestyle (AIBL) Research Group
Nov 2, 2013·NeuroImage. Clinical·Jonathan YoungUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 13, 2014·Nature Reviews. Neurology·Christopher A RossSarah J Tabrizi
Jul 12, 2014·Brain : a Journal of Neurology·Alexandra L YoungUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Apr 17, 2015·IEEE Transactions on Medical Imaging·M Jorge CardosoSebastien Ourselin
Sep 12, 2015·Medical Image Analysis·Alexandra L YoungUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Dec 3, 2015·EBioMedicine·Stefan KlöppelUNKNOWN Track-On investigators
Apr 1, 2016·Journal of Huntington's Disease·Lauren M Byrne, Edward J Wild
Apr 21, 2016·PloS One·Alexander Schmidt-RichbergUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jan 1, 2015·Nature Reviews. Disease Primers·Gillian P BatesSarah J Tabrizi
Dec 17, 2016·Journal of Huntington's Disease·Gary X D'Souza, Henry J Waldvogel
May 19, 2017·Current Opinion in Neurology·Neil P OxtobyUNKNOWN EuroPOND consortium
Jun 29, 2017·Human Brain Mapping·Dan WuUNKNOWN PREDICT-HD Investigators and Coordinators of the Huntington Study Group
Oct 27, 2017·Frontiers in Neurology·Eileanoir B JohnsonRachael I Scahill

❮ Previous
Next ❯

Citations

Oct 17, 2018·Nature Communications·Alexandra L YoungUNKNOWN Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Sep 14, 2018·Science Translational Medicine·Lauren M ByrneEdward J Wild
Feb 28, 2020·Annals of Neurology·Peter A WijeratneDaniel C Alexander
Jun 4, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Nicholas C FirthNeil P Oxtoby
Nov 24, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Rosalyn HithersayAndre Strydom
Nov 20, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Brendan TanNellie Georgiou-Karistianis
Jan 9, 2021·NeuroImage. Clinical·Iris DekkerViktor Wottschel
Feb 6, 2021·Brain : a Journal of Neurology·Neil P OxtobyRimona S Weil
Dec 18, 2020·Science Translational Medicine·Filipe B RodriguesEdward J Wild
Jun 8, 2021·Frontiers in Big Data·Damiano ArchettiUNKNOWN for Alzheimer’s Disease Neuroimaging Initiative and EuroPOND Consortium
Aug 31, 2021·Frontiers in Artificial Intelligence·Alexandra L YoungUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Oct 9, 2021·Frontiers in Neurology·Kirsi M KinnunenUNKNOWN Huntington's Disease Regulatory Science Consortium (HD-RSC)

❮ Previous
Next ❯

Software Mentioned

Geodesic Information Flows ( GIF )
Freesurfer

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

Developmental Medicine and Child Neurology
V S Caviness
Ryōikibetsu shōkōgun shirīzu
Fumitoshi KodakaHiroo Kasahara
Alabama Medicine : Journal of the Medical Association of the State of Alabama
F A Lacour
© 2022 Meta ULC. All rights reserved