An Immediate and Long-Term Complication of COVID-19 May Be Type 2 Diabetes Mellitus: The Central Role of β-Cell Dysfunction, Apoptosis and Exploration of Possible Mechanisms

Cells
Melvin R Hayden

Abstract

The novel coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was declared a pandemic by the WHO on 19 March 2020. This pandemic is associated with markedly elevated blood glucose levels and a remarkable degree of insulin resistance, which suggests pancreatic islet β-cell dysfunction or apoptosis and insulin's inability to dispose of glucose into cellular tissues. Diabetes is known to be one of the top pre-existing co-morbidities associated with the severity of COVID-19 along with hypertension, cardiocerebrovascular disease, advanced age, male gender, and recently obesity. This review focuses on how COVID-19 may be responsible for the accelerated development of type 2 diabetes mellitus (T2DM) as one of its acute and suspected long-term complications. These observations implicate an active role of metabolic syndrome, systemic and tissue islet renin-angiotensin-aldosterone system, redox stress, inflammation, islet fibrosis, amyloid deposition along with β-cell dysfunction and apoptosis in those who develop T2DM. Utilizing light and electron microscopy in preclinical rodent models and human islets may help to better understand how COVID-19 accelerates islet and β-cell inju...Continue Reading

References

Jun 1, 1993·Diabetes·J R WilliamsonR G Tilton
May 13, 1999·The Journal of Endocrinology·M TahmasebiG P Vinson
Dec 10, 1999·Diabetes Research and Clinical Practice·J R WilliamsonY Ido
Jul 4, 2001·Journal of Molecular Endocrinology·P S Leung, P O Carlsson
Dec 4, 2001·Biochimica Et Biophysica Acta·E T Jaikaran, A Clark
Feb 15, 2003·Journal of Pediatric Endocrinology & Metabolism : JPEM·Nurit KaiserRafael Nesher
Apr 5, 2003·The International Journal of Biochemistry & Cell Biology·Po Sing Leung, Mark C Chappell
Jun 28, 2003·Diabetes·Bruce B DuncanUNKNOWN Atherosclerosis Risk in Communities Study
Jan 16, 2007·The Journal of Physiology·Po Sing Leung
May 5, 2007·Antioxidants & Redox Signaling·Melvin R Hayden, James R Sowers
Aug 7, 2007·Journal of the Cardiometabolic Syndrome·Guido LastraMelvin R Hayden
Aug 9, 2007·Journal of the Cardiometabolic Syndrome·Melvin R Hayden
Mar 4, 2008·Endocrine Reviews·Leena HaatajaPeter C Butler
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Ji-Won KimKun-Ho Yoon
Jul 2, 2008·Diabetes Care·Earl S FordNaveed Sattar
Jul 22, 2008·Experimental Biology and Medicine·Melvin R HaydenJames R Sowers
Nov 6, 2008·Journal of the Cardiometabolic Syndrome·Melvin R Hayden, James R Sowers
Dec 10, 2009·Physiology·Marc Y DonathJan A Ehses
Apr 13, 2010·Antioxidants & Redox Signaling·Neelam KhaperPawan K Singal
Apr 5, 2011·Trends in Endocrinology and Metabolism : TEM·Sonya G FonsecaFumihiko Urano
Feb 2, 2012·Cardiorenal Medicine·Melvin R Hayden, James R Sowers
Dec 10, 2013·Lancet·Tiinamaija TuomiLeif Groop
Jul 16, 2014·Journal of Diabetes Research·Liang-Jun Yan
Apr 22, 2015·World Journal of Diabetes·Surapon Tangvarasittichai
Aug 11, 2015·Oxidative Medicine and Cellular Longevity·Kevin Noel KeanePhilip Newsholme
May 23, 2016·Bosnian Journal of Basic Medical Sciences·Tatsuo Tomita
Jul 30, 2016·Current Drug Targets·Thiago Ruiz Rodrigues PrestesAna Cristina Simoes-E-Silva
Aug 16, 2017·Journal of Molecular Endocrinology·Daniel RaleighAnne Clark
Apr 11, 2019·Physiology·Sonia M Najjar, Germán Perdomo

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Citations

Jan 12, 2021·Frontiers in Medicine·Claudia Stöllberger, Maria Winkler-Dworak
Jun 3, 2021·Vaccines·Helena C MaltezouAthanasios Tsakris
Jun 3, 2021·International Journal of Molecular Sciences·Melvin R Hayden, William A Banks
Jun 12, 2021·Nature Communications·Charlotte SteenblockStefan R Bornstein
Jul 3, 2021·Journal of Clinical Medicine·Modesto M Maestre-MuñizAlfredo J Lucendo

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Methods Mentioned

BETA
light
transmission electron microscopy
transgenic
transfection

Related Concepts

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CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis