An Immune-Related Six-lncRNA Signature to Improve Prognosis Prediction of Glioblastoma Multiforme

Molecular Neurobiology
Meng ZhouJie Sun

Abstract

Recent studies have demonstrated the utility and superiority of long non-coding RNAs (lncRNAs) as novel biomarkers for cancer diagnosis, prognosis, and therapy. In the present study, the prognostic value of lncRNAs in glioblastoma multiforme was systematically investigated by performing a genome-wide analysis of lncRNA expression profiles in 419 glioblastoma patients from The Cancer Genome Atlas (TCGA) project. Using survival analysis and Cox regression model, we identified a set of six lncRNAs (AC005013.5, UBE2R2-AS1, ENTPD1-AS1, RP11-89C21.2, AC073115.6, and XLOC_004803) demonstrating an ability to stratify patients into high- and low-risk groups with significantly different survival (median 0.899 vs. 1.611 years, p = 3.87e-09, log-rank test) in the training cohort. The six-lncRNA signature was successfully validated on independent test cohort of 219 patients with glioblastoma, and it revealed superior performance for risk stratification with respect to existing lncRNA-related signatures. Multivariate Cox and stratification analysis indicated that the six-lncRNA signature was an independent prognostic factor after adjusting for other clinical covariates. Further in silico functional analysis suggested that the six-lncRNA sign...Continue Reading

References

May 24, 2007·Cancer·Sith SathornsumeteeJeremy N Rich
Nov 3, 2007·Genes & Development·Frank B FurnariWebster K Cavenee
Sep 6, 2008·Nature·UNKNOWN Cancer Genome Atlas Research Network
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Feb 26, 2009·Cell·Chris P PontingWolf Reik
Oct 1, 2008·The Permanente Journal·Mohammad Sami Walid
Apr 15, 2011·Molecular Cancer·Ewan A GibbWan L Lam
Nov 15, 2011·Molecular Oncology·S Patrick Nana-Sinkam, Carlo M Croce
Mar 7, 2012·Journal of Molecular Endocrinology·Yunli ZhouAnne Klibanski
Sep 18, 2012·BMC Medical Genomics·Elodie VauléonMarc Aubry
Sep 22, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Peng Qi, Xiang Du
Feb 28, 2013·International Journal of Molecular Sciences·Nina Hauptman, Damjan Glavač
Mar 7, 2013·Nature Structural & Molecular Biology·Tim R Mercer, John S Mattick
Mar 27, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Tony GutschnerSven Diederichs
May 23, 2013·RNA Biology·Lina MaZhang Zhang
Jun 1, 2013·BMC Biology·Aleksandra E KornienkoFlorian M Pauler
Jun 4, 2013·Neurobiology of Disease·Xiao-Qin ZhangGilberto Ka-Kit Leung
Jun 4, 2013·Nature Structural & Molecular Biology·Zhou DuX Shirley Liu
May 21, 2014·Neuro-oncology·Quinn T OstromJill S Barnholtz-Sloan
Jun 14, 2014·Science·Anoop P PatelBradley E Bernstein
Aug 12, 2014·Cell Research·Per Johnsson, Kevin V Morris
Oct 15, 2014·EMBO Molecular Medicine·Steven K CarlssonClaes Wahlestedt
Jan 20, 2015·Nature Genetics·Matthew K IyerArul M Chinnaiyan
Apr 11, 2015·Cancer Biology & Medicine·Mohammadreza Hajjari, Abbas Salavaty
Jun 27, 2015·Proceedings of the National Academy of Sciences of the United States of America·Chiara PastoriClaes Wahlestedt
Jul 23, 2015·Genes·Mark R Pickard, Gwyn T Williams
Sep 13, 2015·Journal of Experimental & Clinical Cancer Research : CR·Meng ZhouJie Sun
Nov 6, 2015·Nature Medicine·Maite Huarte
Dec 5, 2015·Briefings in Functional Genomics·Swathi Mohankumar, Tushar Patel

❮ Previous
Next ❯

Citations

Jan 9, 2018·Radiation Research·Molykutty J AryankalayilC Norman Coleman
Nov 6, 2018·Molecular Neurobiology·Manjari KiranAnindya Dutta
Nov 5, 2019·Frontiers in Bioengineering and Biotechnology·Tong MengLiming Cheng
May 20, 2020·Frontiers in Bioengineering and Biotechnology·Yang WangLixin Ma
Aug 28, 2020·Frontiers in Cell and Developmental Biology·Jing LiuXinhong Wang
Mar 27, 2020·Frontiers in Bioengineering and Biotechnology·Junfeng ZhuQi Zhao
Dec 29, 2020·Frontiers in Immunology·Hongbo ZhangLiang Shen
Feb 3, 2021·Journal of Molecular Neuroscience : MN·Wu XuYa-Wen Pan
Nov 1, 2020·Cells·Christian T StackhouseChristopher D Willey

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
biopsy

Software Mentioned

DAVID Bioinformatics Resources
ZhangSig
ceRNA
ceRSig
Cytoscape

Related Concepts

Related Feeds

Cancer Stem Cells in Glioblastoma

Glioblastoma is the most common and aggressive type of brain tumor. It contains a population of tumor initiating stem cell-like cells known as cancer stem cells. Investigations are ongoing into these cancer stem cells found in these solid tumors which are highly resistance to treatment. Here is the latest research on cancer stem cells in glioblastoma.