PMID: 8944760Nov 1, 1996Paper

An immune response to ice crystals in North Atlantic fishes

European Journal of Biochemistry
J M VerdierC L Hew

Abstract

In mammals, the presence of crystals composed of small organic molecules, including urate and related compounds, has been shown to trigger an inflammatory response and the subsequent production of specific immunoglobulins (Ig's). Many fishes that are exposed to ice crystals in cold temperate and polar oceans may harbour ice crystals internally. Here, we report evidence for a specific immune response to ice crystals in cold-ocean marine fishes. Using ice nucleation activity as an assay, anti-ice Ig's were detected in the sera of the cold-ocean marine fish species, ocean pout (Macrozoarces americanus) and Atlantic herring (Clupea harengus harengus), but not in the sera of species that are not exposed to ice. Purified Ig's isolated from ocean pout serum using two different protocols showed ice nucleation activity, thus demonstrating the presence of ice binding specificity among these Ig's.

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Citations

Mar 10, 2001·The International Journal of Biochemistry & Cell Biology·J Barrett
Jan 4, 2003·Nature Cell Biology·Karin Römisch, Tom Matheson
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·N St ClairA L Margolin
Feb 22, 2001·Annual Review of Physiology·G L FletcherP L Davies
Oct 23, 2012·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Rod S Hobbs, Garth L Fletcher
Feb 21, 2004·FEMS Microbiology Reviews·D GeorletteC Gerday
Jan 26, 2008·Accounts of Chemical Research·Lia AddadiRoy Ziblat

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