PMID: 7539881Feb 1, 1995Paper

An immunohistochemical analysis of 13 cases with combined hepatocellular and cholangiocellular carcinoma

Liver
J Haratake, H Hashimoto

Abstract

Thirteen cases of combined hepatocellular (HCC) and cholangiocellular carcinoma (CCC) were examined. In addition to routine pathology, immunoreactivities for carcinoembryonic antigen, alpha-fetoprotein (AFP), cytokeratin (Cam 5.2 and AE1), epithelial membrane antigen (EMA) and tumor-associated glycoprotein 72 (B72.3) were also examined. The average age of the 13 cases was 64.8 years, which lay between the average ages of pure HCC and CCC cases. They were categorized as separate type (2), collision type (6), and intermingled type (5). AE1 and EMA were the best markers to differentiate the CCC from the HCC area. B72.3 immunoreactivity was detected only in CCC (46%). There were no transitional features between HCC and CCC in two cases of the separate type and two cases of the collision type. However, focal transitional features from HCC to CCC were observed in all cases of the intermingled type and in four of six cases of the collision type. In one case of the intermingled type, many cancer cells contained both bile and mucus simultaneously, and revealed dual immunoreactivities. The conclusions are: 1) the combined type is generated from two sources; one is the intrahepatic double cancer (thoroughly separate type and a part of the...Continue Reading

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Citations

Apr 21, 1999·The Journal of Pathology·A E BartmanS B Ho
Apr 15, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Chikako ZenAlberto Quaglia
Oct 3, 2018·Journal of Clinical and Translational Hepatology·Düriye Betül YılmazGülsüm Özlem Elpek
Jul 12, 2011·Journal of Hepato-biliary-pancreatic Sciences·Qian ZhanHong-Wei Li
Feb 27, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Georgios P FragulidisDionysios C Voros
Jun 27, 2013·The Journal of Veterinary Medical Science·Anusha Hemamali TennakoonJyoji Yamate
Oct 22, 2015·American Journal of Clinical Pathology·Rajen GoyalGiovanna A Giannico
Feb 6, 1998·Journal of Clinical Gastroenterology·T IsaT Toda
Oct 31, 2006·World Journal of Gastroenterology : WJG·Louis Libbrecht
Apr 19, 2003·Journal of Computer Assisted Tomography·Osama EbiedValérie Vilgrain
Aug 14, 2010·Avian Pathology : Journal of the W.V.P.A·A J Van WettereH John Barnes
Mar 4, 2008·The Korean Journal of Internal Medicine·Chang Kyun HongJin Young Yoo
Sep 26, 2014·World Journal of Gastroenterology : WJG·Yan-Ming ZhouJia-Mei Yang
Aug 22, 2012·Journal of Hepato-biliary-pancreatic Sciences·Toshio KokuryoMasato Nagino
Jun 19, 2010·ANZ Journal of Surgery·Gianpiero GravanteDavid M Lloyd
Mar 5, 2016·Surgical Case Reports·Hideki IzumiToshio Nakagohri
Aug 10, 2006·Virchows Archiv : an International Journal of Pathology·Monica T GarciaAlan Livingstone

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