An immunohistochemical analysis of endometrial stromal and smooth muscle tumors of the uterus: a study of 54 cases emphasizing the importance of using a panel because of overlap in immunoreactivity for individual antibodies

The American Journal of Surgical Pathology
Esther OlivaPhilip B Clement

Abstract

The expression of desmin, h-caldesmon, calponin, CD10, CD34, CD99, inhibin, and keratin (AE1/3-Cam 5.2) was studied in 10 conventional leiomyomas, 9 highly cellular leiomyomas, 9 epithelioid smooth muscle tumors, 9 leiomyosarcomas, 10 endometrial stromal tumors (4 with smooth muscle metaplasia), and 7 uterine tumors resembling ovarian sex cord tumors (UTROSCTs). c-kit expression was tested in 10 endometrial stromal tumors, 7 UTROSCTs, and 9 leiomyosarcomas. Desmin was positive in almost all smooth muscle tumors except those of epithelioid type, which were positive in only about half of the cases. It also stained areas of smooth muscle differentiation in endometrial stromal tumors and five of seven UTROSCTs. h-caldesmon was positive in almost all nonepithelioid smooth muscle tumors and in areas of smooth muscle differentiation in endometrial stromal tumors; it was positive in only about half of the epithelioid smooth muscle tumors and negative in all UTROSCTs. Calponin was positive in most tumor types. CD10 was positive in nine of 10 endometrial stromal tumors and five of seven UTROSCTs, although very focally in the latter group. It was also expressed, however, in almost all leiomyosarcomas, almost 50% of highly cellular leiomyo...Continue Reading

References

Mar 1, 1991·Human Pathology·A I Farhood, J Abrams
Jan 1, 1991·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·S W BinderS al-Jitawi
Jan 1, 1983·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·C Bonazzi del PoggettoE Saksela
Nov 1, 1994·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A LammieC Cordon-Cardo
Jan 1, 1995·Virchows Archiv : an International Journal of Pathology·A E Lindenmayer, M Miettinen
May 1, 1997·The American Journal of Surgical Pathology·M RishiF A Tavassoli
Feb 25, 1998·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·M A RiopelM E Sherman
Aug 26, 1998·The American Journal of Surgical Pathology·E OlivaR E Scully
Sep 16, 1998·The American Journal of Surgical Pathology·S KrishnamurthyJ Rosai
Feb 6, 1999·Advances in Anatomic Pathology·X Matias-Guiu, J Prat
May 18, 1999·Journal of the National Cancer Institute·A HoriuchiS Fujii
Oct 30, 1999·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·E OlivaR E Scully
Apr 11, 2000·The American Journal of Surgical Pathology·R K YantissR H Young
Jan 11, 2001·Archives of Pathology & Laboratory Medicine·L W ElmoreR T Burks
Feb 24, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·W G McCluggage
Mar 21, 2001·The American Journal of Surgical Pathology·M R NucciB J Quade
May 16, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·P G ChuK L Chang
Jan 10, 2002·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Toshihiko TokiIkuo Konishi

❮ Previous
Next ❯

Citations

Apr 30, 2002·The American Journal of Surgical Pathology·Adriana DionigiRobert H Young
Feb 28, 2003·Advances in Anatomic Pathology·Marisa R NucciChristopher P Crum
Jan 20, 2005·Der Pathologe·A M MüllerU Mittelkötter
Apr 13, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·G KirD Bulbul
May 17, 2005·Applied Immunohistochemistry & Molecular Morphology : AIMM·Jimmy J CaudellLois M Ramondetta
Apr 25, 2006·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·W Glenn McCluggage
Jan 2, 2007·The American Journal of Surgical Pathology·Karen W Simpson, Jorge Albores-Saavedra
Aug 22, 2009·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Isela MolinaAdrian Suarez
Feb 25, 2010·Advances in Anatomic Pathology·Ivy Chew, Esther Oliva
Nov 19, 2010·The American Journal of Surgical Pathology·Laurence de LevalEsther Oliva
Aug 16, 2011·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·M J MentrikoskiH Xu
Dec 6, 2012·The American Journal of Surgical Pathology·Emanuela D'AngeloJaime Prat
Nov 15, 2014·International Archives of Medicine·Atif Ali HashmiMehmood Khan
Feb 13, 2015·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Ryan J CarrNatalia Buza
Dec 31, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Esther Oliva
Mar 25, 2017·Expert Review of Molecular Diagnostics·Ben Davidson, Francesca Micci
Jun 24, 2017·Virchows Archiv : an International Journal of Pathology·Ben DavidsonBetina Katz
Sep 5, 2017·Diagnostic Cytopathology·Yasuto KondoYukitoshi Satoh
Dec 1, 2017·Journal of Clinical Pathology·Elisabetta Kuhn, Ayse Ayhan
Feb 17, 2018·Veterinary Pathology·James K ChambersKazuyuki Uchida
Jul 31, 2018·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Maysa Al-HussainiShaymaa Ashi Al-Loh
Mar 26, 2019·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M LudovisiA C Testa
Sep 11, 2020·International Journal of Surgical Pathology·Michela LibertiniRobin L Jones
Mar 27, 2003·The American Journal of Surgical Pathology·Lisa A CerilliStacey E Mills
Jun 17, 2005·The American Journal of Surgical Pathology·Julie A IrvingRobert H Young
Nov 25, 2005·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Masato NakayamaMichio Shimizu
Mar 22, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Walter M Klein, Robert J Kurman
May 22, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Esther OlivaRobert H Young
Sep 22, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Esther OlivaRobert H Young
Feb 13, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A AndroulakiA C Lazaris
Dec 25, 2007·Advances in Anatomic Pathology·Andrew N YoungMahul B Amin
Mar 5, 2013·Archives of Pathology & Laboratory Medicine·Shaymaa Al-Loh, Maysa Al-Hussaini
Dec 17, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Riitta Koivisto-KoranderArto Leminen
Sep 28, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Carlos E Parra-HerranBradley J Quade
Jul 29, 2015·Vascular Specialist International·Mi-Hyeong KimJi-Il Kim
Feb 7, 2018·Applied Immunohistochemistry & Molecular Morphology : AIMM·Siavash RahimiChit Cheng Yeoh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Jianfang LiangHuixia Zheng
International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
V P SumathiW Glenn McCluggage
© 2022 Meta ULC. All rights reserved