PMID: 15381902Sep 24, 2004Paper

An immunohistochemical analysis of ovarian small cell carcinoma of hypercalcemic type

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
W G McCluggageR H Young

Abstract

Ovarian small cell carcinoma of hypercalcemic type (OSCCHT) is a rare neoplasm with an aggressive behavior, broad differential diagnosis, and unknown histogenesis. To add to knowledge concerning the possible aid of immunohistochemistry in resolving problems in differential diagnosis and to further explore whether that modality points to any specific histogenesis, we undertook an immunohistochemical study of this neoplasm. Fifteen OSCCHTs (including four of the ''large cell" variant) were stained with a range of antibodies, some of which have not been investigated previously in this neoplasm. Cases were stained with AE1/3, EMA, BerEP4, CK5/6, calretinin, WT1, chromogranin, CD56, synaptophysin, CD99, NB84, desmin, S100, CD10, alpha inhibin, TTFI, and p53. Staining was classified as 0 (negative), 1+ (<5% cells positive), 2+ (5% to 25% cells positive), 3+ (26% to 50% cells positive), or 4+ (>50% cells positive). All cases were positive with p53 (two 1+, five 3+, eight 4+), 14 of 15 cases were positive with WT1 (one 1+, thirteen 4+), 14 of 15 with CD10 (three 1+, four 2+, two 3+, five 4+), 13 of 15 with EMA (three 1+, three 2+, two 3+, five 4+), 11 of 15 with calretinin (nine 1+, one 3+, one 4+), 9 of 15 with AE1/3 (eight 1+, one 2+...Continue Reading

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Citations

May 16, 2006·The American Journal of Surgical Pathology·W Glenn McCluggage, Robert H Young
Apr 25, 2006·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·W Glenn McCluggage
Sep 23, 2006·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·W Glenn McCluggageRobert H Young
Apr 26, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Nelson G Ordóñez
Aug 28, 2007·The American Journal of Surgical Pathology·Chengquan ZhaoRussell Vang
Nov 18, 2008·The American Journal of Surgical Pathology·Michele BiscegliaJuan Rosai
Sep 22, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Esther OlivaRobert H Young
Feb 4, 2009·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·V PhillipsW Glenn McCluggage
May 31, 2011·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Sorsiah MansorW Glenn McCluggage
Aug 2, 2011·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Raji GanesanW Glenn McCluggage
Oct 1, 2009·Pathology International·Yukinori InadomeMasayuki Noguchi
Jun 15, 2007·Journal of Clinical Pathology·W Glenn McCluggageCyril Fisher
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Mar 1, 2011·Surgical Pathology Clinics·W Glenn McCluggage
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