PMID: 22553816May 4, 2012Paper

An immunohistochemical study of adenomatoid tumors of the uterus and fallopian tube

Applied Immunohistochemistry & Molecular Morphology : AIMM
Tadashi Terada

Abstract

Immunohistochemical studies of adenomatoid tumor (AT) are rare in the English literature. The author reports herein immunoprofile of AT of the female genital organs. The materials are 4 cases of AT of the uterus and 1 case of AT of the fallopian tube. The ages of the patients were 37, 41, 43, 45, and 56 years. The sizes of ATs were 0.8 cm, 1 cm, 1.5 cm, 2 cm, and 4 cm. The 4 ATs of the uterus were composed of tubules and smooth muscles, whereas 1 AT of the fallopian tube was composed only of tubules. Immunohistochemically, the ATs were consistently positive for pancytokeratin AE1/3+++, pancytokeratin CAM5.2 ++, cytokeratin (CK) 7 +++, CK8 +, CK18++, CK19++, calretinin +++, and D2-40 ++. Estrogen receptor (ER) and progesterone receptor (PgR) was positive in 4 of 5 cases. CK34βE12 was positive in 1 of 5 case. The Ki-67 labeling ranged from 0.2% to 3%. The smooth muscles in uterine ATs were positive for α-smooth muscle actin, ER, and PgR. The ATs were consistently negative for CK5/6, CK14, CK20, EMA, HMB45, vimentin, desmin, CD31, CD34, factor VIII-relatedantigen, S100 protein, p53, CD68, CDK4, MDM2, and Ber-EP4. These data indicate that ATs consistently express pancytokeratin AE1/3, pancytokeratin CAM5.2, CK7, CK8, CK18, CK19, ca...Continue Reading

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Citations

Mar 28, 2013·Applied Immunohistochemistry & Molecular Morphology : AIMM·Nelson G Ordóñez
Jul 21, 2017·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Tomohiko MatsuhashiToshiyuki Takeshita
Feb 4, 2016·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Fereshteh MohammadizadehMarzieh Bagheri
May 29, 2015·Journal of Computer Assisted Tomography·Qiuhua MengXinchun Li

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