An immunohistochemical study of bcl-2 and p53 protein expression in pancreatic carcinomas

Scandinavian Journal of Gastroenterology
G OhshioM Imamura

Abstract

Only a few articles have examined the relationship between bcl-2 expression and clinical findings or bcl-2 expression and p53 expression in pancreatic carcinomas. We investigated bcl-2 protein and p53 protein expression by means of immunohistochemical methods. The immunostaining for bcl-2 was positive in 16 (20%) of 81 cases of pancreatic carcinoma. There were no significant correlations between bcl-2 expression and the age, gender, region of sampling, or clinical stage of the patients. Bcl-2 protein was detected more frequently in histologically high-grade pancreatic carcinomas (grade III, 31%; grade II, 14%; grade I, 0%); however, there was no significant difference in prognosis between patients with and without bcl-2 protein expression. Immunostaining for the p53 protein was positive in 45 (56%) of 81 cases of pancreatic carcinoma. There was no significant correlation between bcl-2 protein expression and p53 protein expression. Bcl-2 was often detected in histologically high-grade pancreatic carcinomas, although there was no significant correlation between bcl-2 expression and the prognosis.

References

Oct 8, 1992·Nature·R P BissonnetteD R Green
Jun 1, 1993·American Journal of Clinical Pathology·I A DoussisD Y Mason
Sep 2, 1993·The New England Journal of Medicine·F PezzellaD Y Mason

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Citations

Oct 7, 2006·Current Opinion in Gastroenterology·R H HrubanS E Kern
Nov 21, 2007·Expert Opinion on Therapeutic Targets·Giuseppe ToniniDaniele Santini
Oct 10, 2002·Applied Immunohistochemistry & Molecular Morphology : AIMM·E J GarciaC Cohen
Mar 31, 2011·British Journal of Cancer·R A SmithP Ghaneh
Aug 28, 2001·The Journal of Pathology·D CampaniG Bevilacqua

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