PMID: 6538179Mar 1, 1984Paper

An immunohistochemical study of human central and peripheral nervous system tumors, using monoclonal antibodies against neurofilaments and glial filaments

Human Pathology
J Q TrojanowskiW W Schlaepfer

Abstract

Monoclonal antibodies that recognize either neurofilaments or glial filaments were used with the peroxidase-antiperoxidase (PAP) method to retrospectively study 100 tumors of the central and peripheral nervous systems in paraffin-embedded sections. Only neoplasms of putative neuronal origin or with presumed neuronal differentiation (paraganglioma, ganglioglioma, ganglioneuroblastoma, ganglioneuroma, neuroblastoma, ovarian teratoma and pheochromocytoma) contained tumor cells with immunoreactive neurofilament, but such cells were more common in the more differentiated or benign neoplasms in this category. Glial filament immunoreactivity was observed in tumor cells of glial origin and in tumor cells with foci of glial differentiation arising within the central nervous system, consistent with findings from previous studies using anti-glial-filament antisera. With the exception of a benign cystic teratoma, no glial filament immunoreactivity was observed outside the central nervous system. Some immunoreactive neurofilaments, but not glial filaments, were arranged in presumably abnormal balls, cords, or clumps within tumor cells, possibly reflecting cytoskeletal alterations related to neoplastic transformation. These findings indicate...Continue Reading

References

Jul 1, 1977·Journal of Neuropathology and Experimental Neurology·P E DuffyM M Rapport
Sep 25, 1981·Science·P GambettiS C Papasozomenos
Sep 1, 1982·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·D DahlA Bignami
Sep 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·W F HickeyN K Gonatas
Jan 1, 1983·Acta Neuropathologica·J Q Trojanowski, V M Lee
Sep 15, 1982·International Journal of Cancer. Journal International Du Cancer·A J CochranR B Gaynor
Nov 1, 1982·Experimental Cell Research·S H Blose, A Bushnell
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·V LeeW W Schlaepfer
Jan 1, 1981·Acta Neuropathologica·L J Rubinstein, J M Brucher
Dec 7, 1981·Brain Research·W W SchlaepferH L Wu
Mar 1, 1982·Journal of Neuropathology and Experimental Neurology·M E VelascoP Gambetti
Nov 1, 1982·Cancer·J Q TrojanowskiL B Rorke
Aug 1, 1981·Developmental Biology·S J TapscottH Holtzer
Jul 15, 1982·The New England Journal of Medicine·J Q TrojanowskiS Lee
May 1, 1981·Human Pathology·L J Rubinstein

❮ Previous
Next ❯

Citations

Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·P LoddingG Stenman
Dec 1, 1990·Journal of Cutaneous Pathology·Z B Argenyi
Jan 1, 1990·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·A OgawaM Tamura
Jun 15, 1990·International Journal of Cancer. Journal International Du Cancer·B BodeyJ Kemshead
Jan 1, 1985·Ultrastructural Pathology·S P Hammar, J W Bolen
Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·K SchwechheimerW W Franke
Oct 25, 2006·Acta Neuropathologica·Fausto J RodriguezGary W Mierau
Apr 1, 1988·Histopathology·R W StirlingC D Fletcher
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·N KimuraY Nakazato
Oct 29, 1997·The Journal of Veterinary Medical Science·Y OkazakiM Tsuchitani
Jan 1, 1985·Annals of the New York Academy of Sciences·I VirtanenR Paasivuo
Apr 1, 1992·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·S BirgissonK Olafsdottir
Dec 1, 1996·Cancer Metastasis Reviews·C L Ho, R K Liem
Apr 1, 1993·Journal of Cutaneous Pathology·Z B Argenyi
Jan 1, 1989·British Journal of Neurosurgery·P J SimeJ E Bell
Jul 11, 1985·The New England Journal of Medicine·J Q Trojanowski, V M Lee
Mar 1, 1989·Ultrastructural Pathology·R A Erlandson
Jan 1, 1987·Ultrastructural Pathology·B W Scheithauer, J M Bruner
Sep 1, 1986·Environmental Health Perspectives
Oct 23, 1989·Brain Research·P G Galloway, M J Likavec
Sep 1, 1984·Annals of Neurology·J Q TrojanowskiW W Schlaepfer
Mar 1, 1986·Human Pathology·M DrijkoningenV Desmet

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.