PMID: 7520348Sep 1, 1994Paper

An immunohistochemical study of p53 protein in gallbladder and extrahepatic bile duct/ampullary carcinomas

Cancer
M TehG C Raju

Abstract

p53 mutations are known to occur frequently in human cancers, including gallbladder carcinoma. However, there has been no study of p53 expression in extrahepatic bile duct/ampullary carcinoma. Furthermore, gallbladder carcinoma is associated with cholelithiasis, whereas no such association is known for extrahepatic bile duct carcinoma, suggesting that they could arise from different pathogenetic mechanisms. Twenty-four gallbladder carcinomas and 35 extrahepatic bile duct/ampullary carcinomas were stained with an anti-human p53 protein monoclonal antibody by the streptavidin-biotin immunoperoxidase method. Both the extent and intensity of p53 protein staining were noted. Ninety-two percent of the gallbladder carcinomas stained for p53 protein compared with only 66% of the extrahepatic bile duct/ampullary carcinomas. The statistical significance was maintained even when the comparison was restricted to strong p53 staining in moderately to poorly differentiated adenocarcinomas (P < 0.05). Of the gallbladder carcinomas, poorly differentiated adenocarcinomas stained more strongly than well to moderately differentiated adenocarcinomas; the converse was true for extrahepatic bile duct/ampullary adenocarcinomas. The majority of gallbla...Continue Reading

References

Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·Y SoiniK Vähäkangas
Sep 1, 1992·British Journal of Cancer·T StarzynskaP L Stern
Apr 1, 1992·International Journal of Cancer. Journal International Du Cancer·H M MartinF Silvestre
Sep 1, 1990·The Journal of Pathology·A L Harris
Oct 1, 1993·British Journal of Cancer·F ChangK Syrjänen

❮ Previous
Next ❯

Citations

Apr 1, 1997·Diagnostic Cytopathology·G Kocjan, A N Smith
Oct 5, 2002·Cancer·Tadahiro TakadaUNKNOWN Study Group of Surgical Adjuvant Therapy for Carcinomas of the Pancreas and Biliary Tract
Jun 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K HanadaG Kajiyama
Jan 1, 2008·Case Reports in Gastroenterology·Atsushi NanashimaTakeshi Nagayasu
Apr 30, 2011·World Journal of Gastrointestinal Oncology·Giulia MalaguarneraClorinda Mazzarino
Jan 22, 2002·International Journal of Cancer. Journal International Du Cancer·Karel CacaFrieder Berr
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Luis A Hidalgo GrauJavier Suñol Sala
Oct 19, 2010·Annals of Diagnostic Pathology·Kemal KosemehmetogluErhan Hamaloglu
Sep 23, 1998·Human Pathology·S JonasP Neuhaus
Apr 4, 2000·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S MisraN C Misra
Aug 13, 1999·The American Journal of Gastroenterology·B ZhaoM Makuuchi
Sep 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I DiamantisA Zimmermann
Aug 24, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ta-Sen YehMiin-Fu Chen
Jan 6, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M TakashimaM Tsuneyoshi
Jun 8, 2000·International Journal of Cancer. Journal International Du Cancer·S YazumiR Takahashi
Mar 30, 2000·Journal of Surgical Oncology·T SutoS i Nakamura
Apr 1, 1996·Liver·K Washington, M R Gottfried
Dec 2, 1998·International Journal of Cancer. Journal International Du Cancer·P D SturmH A Pitt
May 30, 2013·The American Journal of Surgical Pathology·Rita Dorantes-HerediaJorge Albores-Saavedra

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.