PMID: 3298078Jul 15, 1987Paper

An immunohistological study of cells infiltrating progressive and regressive tumors induced by two variant subpopulations of a rat colon cancer cell line

International Journal of Cancer. Journal International Du Cancer
M MartinF Martin


In order to understand the mechanisms leading up to progression or regression, tumors resulting from the s.c. inoculation of progressive or regressive variants of a cell culture established from a chemically-induced rat colonic carcinoma were subjected to sequential histological study. As immunological factors have been previously described in this system of progressive or regressive tumors, special interest was given to inflammatory cells, T and B lymphocytes and macrophages, located inside and outside the tumor. Immunohistological methods using monoclonal or polyclonal antibodies and enzyme histology were performed to identify different populations of infiltrative cells. In both variants of tumors an accumulation of these cells were seen at the periphery of the tumor, surrounding the nodules. In contrast, very few inflammatory cells, macrophages or T lymphocytes were seen inside the clumps of tumor cells where cytolytic cells could have a contact-dependent tumoricidal effect. Only small differences were found between progressive and regressive tumors in the density of the various populations of T helper, T cytotoxic/suppressor, B lymphocytes or macrophages inside or around the tumor nodules. On the other hand, progressive and...Continue Reading


Jul 15, 1986·International Journal of Cancer. Journal International Du Cancer·M S MartinF Martin
Aug 15, 1985·International Journal of Cancer. Journal International Du Cancer·A CaignardF Martin
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Nov 15, 1983·International Journal of Cancer. Journal International Du Cancer·F MartinM Martin
Aug 1, 1980·European Journal of Immunology·R J BrideauA F Williams
Aug 15, 1981·International Journal of Cancer. Journal International Du Cancer·M Key, J S Haskill
Oct 1, 1986·Immunology Today·B FreundlichS A Jimenez

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Apr 10, 1996·International Journal of Cancer. Journal International Du Cancer·P ChauxF Martin
Mar 30, 2000·International Journal of Cancer. Journal International Du Cancer·M Martin, F Martin
May 1, 1996·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·A Zimmermann, H U Baer
Jan 1, 1995·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·V VonarxT Patrice
Sep 1, 1994·Gastroenterology·P PujuguetM Martin
Oct 1, 1990·The Journal of Steroid Biochemistry and Molecular Biology·A BerradaP Lustenberger
Apr 1, 1994·Journal of Photochemistry and Photobiology. B, Biology·M T FoultierT Patrice
Apr 12, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Alessandro CaporaleFrancesco Angelico
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Feb 15, 2001·Investigative Radiology·M LewinG Frija
Oct 12, 2011·Cell and Tissue Research·Vivien J Coulson-ThomasHelena B Nader
Nov 18, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Raju C ReddyTheodore J Standiford
Apr 3, 2003·British Journal of Cancer·D-E HuK M Brindle
Dec 2, 1992·International Journal of Cancer. Journal International Du Cancer·R ZennadiJ Le Pendu
Nov 15, 1987·International Journal of Cancer. Journal International Du Cancer·T ShimizuF Martin
Feb 20, 1993·International Journal of Cancer. Journal International Du Cancer·D ReisserF Martin
Feb 1, 1994·International Journal of Cancer. Journal International Du Cancer·A MénoretJ Le Pendu
Jul 15, 1988·International Journal of Cancer. Journal International Du Cancer·G M GlennT Borsos

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