An immunological study of germinal centres in four ophthalmic immunocytomas

Virchows Archiv. A, Pathological Anatomy and Histopathology
W M MolenaarK Lennert

Abstract

Four ophthalmic lymphoplasmacytic/lymphoplasmacytoid (LP) immunocytomas with germinal centres were reviewed histologically and studied immunologically by means of the peroxidase-antiperoxidase (PAP) method. In two cases a histological diagnosis of LP immunocytoma was made, while in the other two cases a non-Hodgkin's lymphoma could not be histologically differentiated with certainty from a pseudolymphoma or reactive process. Immunological analysis confirmed the diagnosis in the former two cases and led in one of the latter also to a diagnosis of LP immunocytoma. In the fourth case the development of LP immunocytoma out of a pseudolymphoma could be demonstrated. In the four LP immunocytomas the germinal centres showed a monoclonal pattern of immunoglobulin in one case, a polyclonal pattern in one case and a negative reaction in two cases. The role of germinal centres in relation to the development of LP immunocytoma is discussed.

References

Sep 1, 1977·American Journal of Clinical Pathology·A G KellyS T Kraus
May 1, 1979·American Journal of Ophthalmology·D M KnowlesJ P Halper
May 1, 1979·The Histochemical Journal·B L MephamB S Mitchell
Apr 5, 1976·Virchows Archiv. A, Pathological Anatomy and Histology·E W SchwarzeK Lennert
Sep 1, 1973·Journal of Clinical Pathology·A Garner
May 1, 1980·American Journal of Clinical Pathology·R W AstaritaR J Lukes
Jan 1, 1982·Virchows Archiv. A, Pathological Anatomy and Histology·U SchmidK Lennert

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Citations

Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·U SchmidK Lennert
Oct 1, 1989·The British Journal of Ophthalmology·D Ben-EzraD M Albert
Nov 1, 1987·The Journal of Pathology·P A HallA G Stansfeld
Jan 1, 1985·Archives of Dermatological Research·S C van der PutteJ A van Unnik
Jan 1, 1992·European Journal of Applied Physiology and Occupational Physiology·D L Ballor, A J Volovsek

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