An immunoregulatory peptide from tsetse fly salivary glands of Glossina morsitans morsitans

Biochimie
Xuewei BaiMingqiang Rong

Abstract

Tsetse fly Glossina morsitans morsitans is an important insect vector of African trypanosomes, which cause human African trypanosomiasis (HAT). As other hematophagous arthropods, tsetse fly relies heavily on the pharmacological propriety of their saliva to suppress host's immune reactions and get blood meal. However little information is available on immune regulators from testes fly. An immunoregulatory peptide named Gloss 2 containing amino acid sequence of QKNDTAFSCHFFEIYL SNCFNKEKYIKNYLQIM has been identified from salivary glands of the tsetse fly of G. morsitans morsitans (Diptera: Glossinidae). Gloss 2 has the ability to inhibit the secretion of tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ),interleukin-6 (IL-6) and interleukin-10 (IL-10) induced by lipopolysaccharide (LPS) in mouse splenocytes. Besides, Gloss 2 significantly suppressed the LPS-induced activation of MAPK signaling pathway through blocking phosphorylations of JNK, Erk and P38. Gloss 2 probably inhibits host inflammatory responses by inhibiting secretion of TNF-α, IFN-γ and IL-6. Considering IL-10's ability to promote humoral immune responses by enhancing class II expression B cells and inducing immunoglobulin (Ig) production, Gloss 2 may inhibit hos...Continue Reading

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Citations

Jul 23, 2016·Frontiers in Immunology·Benoît StijlemansCarl De Trez
Jul 22, 2016·PLoS Pathogens·Guy CaljonJan Van Den Abbeele
Jul 27, 2018·Scientific Reports·Guy CaljonJan Van Den Abbeele
Aug 17, 2021·Frontiers in Cellular and Infection Microbiology·Monrat Chulanetra, Wanpen Chaicumpa

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