An Impairment of Prospective Memory in Mild Alzheimer's Disease: A Ride in a Virtual Town

Frontiers in Psychology
Grégory LecouveyBéatrice Desgranges

Abstract

Objective: Research suggests that prospective memory (PM) is impaired from the very early stages of Alzheimer's disease (AD). We sought to further characterize this impairment in patients with mild AD, using a virtual reality (VR) task to provide ecological assessment of PM. Methods: Fifteen cognitively normal older individuals (76.47 years old ± 4.14, MMSE: 28.80 ± 1.21), and 17 patients with mild AD (79.29 years old ± 4.45, MMSE: 22.82 ± 2.83) were asked to recall the prospective and retrospective components of seven intentions in a virtual town task. Six intentions were event-based, where the prospective cue was either highly (three intentions) or weakly (three intentions) associated with the retrospective component. The remaining intention was time-based. All participants completed a neuropsychological assessment of episodic memory, semantic memory and executive functioning. Non-parametric tests were used to compare the two groups on the different intentions types and components. Correlations between cognition and PM scores were then realized to further understand the cognitive correlates of the PM impairment in patients with AD. Results: Overall, patients with Alzheimer disease recalled fewer intentions than controls, with...Continue Reading

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Citations

Oct 13, 2020·Applied Neuropsychology. Adult·Audrey Landuran, Bernard N'Kaoua
Dec 18, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Lulu LiuMuireann Irish
Nov 21, 2020·Sensors·José Varela-AldásIván García-Magariño
Apr 18, 2020·The Clinical Neuropsychologist·Giovanna MioniFranca Stablum

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