An implantable centrifugal blood pump with a recirculating purge system (Cool-Seal system)

Artificial Organs
K YamazakiB P Griffith

Abstract

A compact centrifugal blood pump has been developed as an implantable left ventricular assist system. The impeller diameter is 40 mm, and pump dimensions are 55 x 64 mm. This first prototype, fabricated from titanium alloy, resulted in a pump weight of 400 g including a brushless DC motor. The weight of a second prototype pump was reduced to 280 g. The entire blood contacting surface is coated with diamond like carbon (DLC) to improve blood compatibility. Flow rates of over 7 L/min against 100 mm Hg pressure at 2,500 rpm with 9 W total power consumption have been measured. A newly designed mechanical seal with a recirculating purge system (Cool-Seal) is used for the shaft seal. In this seal system, the seal temperature is kept under 40 degrees C to prevent heat denaturation of blood proteins. Purge fluid also cools the pump motor coil and journal bearing. Purge fluid is continuously purified and sterilized by an ultrafiltration unit which is incorporated in the paracorporeal drive console. In vitro experiments with bovine blood demonstrated an acceptably low hemolysis rate (normalized index of hemolysis = 0.005 +/- 0.002 g/100 L). In vivo experiments are currently ongoing using calves. Via left thoracotomy, left ventricular (LV...Continue Reading

References

Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J W Donovan, E Mihalyi
Jul 1, 1995·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·K YamazakiJ Tomczak
Nov 14, 1997·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·D C ThomasJ F Antaki
Nov 14, 1997·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Y SankaiT Mitsui

❮ Previous
Next ❯

Citations

Dec 14, 2002·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Kenji YamazakiHiromi Kurosawa
Jun 14, 2005·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Setsuo TakataniTakashi Yamane
Aug 27, 2010·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Koichi KashiwaShunei Kyo
Jul 8, 2011·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Yukiko YamadaKenji Yamazaki
Oct 19, 2012·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Takashi YamaneKenji Yamazaki
May 23, 2002·The Annals of Thoracic Surgery·Brian W Duncan
Mar 14, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Paul L DiGiorgiMehmet C Oz
Nov 28, 2001·Artificial Organs·M YoshinoS Takatani
Nov 28, 2001·Artificial Organs·T AkimotoB P Griffith
Feb 13, 2003·Artificial Organs·Shin'ichiro KiharaBartley P Griffith
Dec 25, 2008·Expert Review of Medical Devices·Dong-Choon SinXigeng Miao
Apr 22, 2005·Journal of Oral Rehabilitation·S K KimS S Lee
Aug 5, 2000·Perfusion·H M Reul, M Akdis
Nov 17, 2006·Journal of Biomedical Materials Research. Part a·Trevor A SnyderWilliam R Wagner
Oct 9, 2009·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Shiori Oshima, Yoshiyuki Sankai
Dec 3, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Setsuo TakataniMasaharu Yoshikawa
Feb 24, 2019·Annual Review of Biomedical Engineering·Eleonora Dal SassoLaura Iop
Oct 4, 2000·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·T AkimotoB P Griffith
Jul 27, 2002·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Tomonori TsukiyaHisateru Takano
Jan 30, 2002·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Tomonori TsukiyaHisateru Takano
Aug 17, 2004·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Hiroyuki TanishiroYasuhiro Fukui
Nov 12, 2018·The Journal of Thoracic and Cardiovascular Surgery·Rashad ZayatChristian Bleilevens
Sep 30, 2018·The Journal of Thoracic and Cardiovascular Surgery·Shuab Omer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.