PMID: 8944988Sep 1, 1996Paper

An improved blood substitute. In vivo evaluation of its hemodynamic effects

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
J SimoniM Feola

Abstract

The purpose of the present study was to assess the ability of an improved free hemoglobin based blood substitute to serve as a resuscitative fluid in the treatment of hemorrhagic shock. Comparison studies were performed by using blood autotransfusion as a positive control. The hemodynamic parameters studied included cardiac index, mean arterial pressure, pulse pressure, heart rate, stroke volume index, and total peripheral resistance. Tissue oxygenation was measured in the biceps femori muscle by polarography. Hemorrhagic shock (at 40% of the total blood volume) in anesthetized rats caused severe disturbances in hemodynamic parameters and tissue oxygenation. Shock was characterized by a 66% drop in cardiac index, a 67% drop in mean arterial pressure with a significant increase in total peripheral resistance, and a 78% reduction in tissue oxygenation, all lasting 30 min. Resuscitation from shock with the blood substitute was effective in restoring hemodynamic parameters, producing vasodilation, and improving tissue oxygenation. Autotransfusion with blood also restored hemodynamics. However, lower tissue oxygenation and lack of vasodilation were noted. Therefore, the modified hemoglobin solution yielded better results than blood ...Continue Reading

Citations

Jan 31, 2009·Artificial Organs·Jan SimoniJohn F Moeller
Jul 4, 2013·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Pedro Cabrales, Marcos Intaglietta
Aug 9, 2001·Journal of Clinical Periodontology·M Morita, H L Wang
Nov 26, 2002·Journal of Clinical Periodontology·Marc QuirynenDaniel van Steenberghe
Mar 17, 2004·Journal of Clinical Periodontology·M D CarvalhoG R Nogueira-Filho

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