An improved catalyst for ring-closing alkyne metathesis based on molybdenum hexacarbonyl/2-fluorophenol

Organic Letters
Karol Grela, Jolanta Ignatowska

Abstract

[reaction: see text] An improved "instant" catalyst for ring-closing alkyne metathesis reaction is described. Catalyst formed in situ from molybdenum hexacarbonyl and 2-fluorophenol can be used without exclusion of air and moisture and shows high activity in metathesis of functionalized diynes. This system allows cyclization of substrates which were incompatible with previously known Mo(CO)(6)/phenol catalysts.

References

Dec 19, 2001·Accounts of Chemical Research·Uwe H F Bunz

Citations

May 7, 2005·Chemical Communications : Chem Comm·Alois Fürstner, Paul W Davies
Feb 3, 2011·Beilstein Journal of Organic Chemistry·Xian Wu, Matthias Tamm
Mar 15, 2011·European Journal of Medicinal Chemistry·J Alberto MarcoIsabel Barasoain
Nov 3, 2009·Chemistry : a European Journal·Haruhiko FuwaMakoto Sasaki
Oct 23, 2018·Chemistry : a European Journal·Henrike Ehrhorn, Matthias Tamm
Jul 9, 2005·Angewandte Chemie·K C NicolaouDavid Sarlah
Jan 29, 2013·Angewandte Chemie·Alois Fürstner
May 25, 2012·Angewandte Chemie·Sergej LysenkoMatthias Tamm
Feb 20, 2021·Nature Communications·Yanqing GeWei Zhang

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