Abstract
It is desirable to diagnose hepatocellular carcinoma (HCC) in the early stages during its development since its treatment is usually difficult. We previously proposed a new diagnostic method that made use of the total metallothionein (MT), zinc (Zn), and copper (Cu) concentrations in the liver of the HCC patients. We recently found that MT-1 is involved in the metabolism or detoxification of toxic metals, such as cadmium; on the other hand, MT-2 is responsible for the homeostasis of essential metals such as copper, in experimental models such as Long Evans Cinnamon (LEC) rats. In order to device a better diagnostic method than the one we proposed previously, in this study, we newly propose an improved method that includes the discriminative determination data regarding the MT isomers, namely, MT-1 and MT-2, in the liver of patients with or without HCC as compared with the total MT level. The total MT and Zn concentrations in the HCC patients were confirmed to be significantly lower than those in patients without hepatic disorders (Ctrl). In contrast, Cu concentrations of the HCC patients were higher than those of the Ctrl patients. In addition, in the juxta-tumor portion with HCC, MT-1 concentrations were significantly higher t...Continue Reading
References
Aug 1, 1978·Cancer·S Inutsuka, S Araki
May 15, 1992·Biochemical and Biophysical Research Communications·H SakuraiK Kawano
May 1, 1992·Journal of Hepatology·M Colombo
Jun 15, 1992·Biochemical and Biophysical Research Communications·H SakuraiT Hagino
Jan 1, 1991·Methods in Enzymology·R J Cousins
Jan 1, 1991·Methods in Enzymology·J H Kägi
Jul 1, 1988·Japanese Journal of Cancer Research : Gann·R MasudaM Mori
Jan 1, 1988·Toxicology and Applied Pharmacology·L D Lehman-McKeemanC D Klaassen
Jan 1, 1988·The Biochemical Journal·S Kobayashi, J Sayato-Suzuki
Nov 1, 1987·The Journal of Heredity·M C YoshidaM Mori
Mar 1, 1986·Toxicology·S OnosakaK Yamamoto
Nov 19, 1984·Life Sciences·R A DiSilvestro, R J Cousins
Jun 1, 1980·Toxicology Letters·K T Suzuki, M Yamamura
Dec 15, 1980·Cancer·J A GarofaloR A Good
Apr 1, 1995·British Journal of Cancer·D M KlothM G Cherian
Apr 30, 1993·Biochemical and Biophysical Research Communications·H SakuraiT Hagino
Oct 25, 1996·Journal of Chromatography. B, Biomedical Applications·T MinamiY Okazaki
Jul 17, 1998·Analytical Chemistry·H Chassaigne, R Lobinski
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·R D Palmiter
Jan 14, 1999·Radiology·M EbaraH Saisho
Apr 8, 2000·Critical Reviews in Biochemistry and Molecular Biology·A T MilesV Rodilla
May 10, 2000·The Journal of Nutrition·S R Davis, R J Cousins
Jul 13, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·K KuboT Minami
Oct 6, 2000·Journal of Hepatology·M EbaraH Sakurai
Feb 24, 2001·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·M C YuR K Ross
May 9, 2002·Biological & Pharmaceutical Bulletin·Akihiro NakayamaHiromu Sakurai
Nov 27, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Takeshi MinamiKanenobu Kubo
Jul 14, 2004·Biochemical and Biophysical Research Communications·Shunsuke NakamuraHiromu Sakurai
Jul 6, 2005·Biological & Pharmaceutical Bulletin·Satoshi KuboHiromu Sakurai
Citations
Sep 5, 2012·Bioanalysis·Fred van HeuvelnJaap Wieling
Nov 3, 2012·The Tohoku Journal of Experimental Medicine·Soisungwan Satarug, Michael R Moore
Apr 6, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Nobuhiko Miura, Shinji Koizumi
Jul 27, 2007·Life Sciences·Tridib ChakrabortyMalay Chatterjee
Jan 23, 2014·Cancer Biology & Therapy·Leslie C Costello, Renty B Franklin
Jan 3, 2007·Journal of Mass Spectrometry : JMS
Mar 30, 2007·Journal of Separation Science·Rania BakryGünther K Bonn
Aug 10, 2007·Archives of Environmental Contamination and Toxicology·Julieta WernerAlison Yarmill
Sep 5, 2007·Electrophoresis·Andrei R Timerbaev
Mar 30, 2010·Electrophoresis·Ana Valéria Colnaghi SimionatoMarina Franco Maggi Tavares
Jan 10, 2012·Electrophoresis·Marketa RyvolovaRene Kizek
May 30, 2019·PloS One·Shafinaz Abd GaniSharida Fakurazi
Nov 30, 2019·Current Pharmaceutical Biotechnology·Qingyun JiaLan Wang
Jun 3, 2015·World Journal of Gastroenterology : WJG·Jiang LiZhong-Yang Shen
Aug 14, 2020·International Journal of Molecular Sciences·Daisy L WongMartin J Stillman
Oct 13, 2012·Chemical Reviews·Andrei R Timerbaev
Jun 16, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Farid E Ahmed