An Improved Dynamic Model for the Respiratory Response to Exercise

Frontiers in Physiology
Leidy Y SernaRoberto A Rabinovich

Abstract

Respiratory system modeling has been extensively studied in steady-state conditions to simulate sleep disorders, to predict its behavior under ventilatory diseases or stimuli and to simulate its interaction with mechanical ventilation. Nevertheless, the studies focused on the instantaneous response are limited, which restricts its application in clinical practice. The aim of this study is double: firstly, to analyze both dynamic and static responses of two known respiratory models under exercise stimuli by using an incremental exercise stimulus sequence (to analyze the model responses when step inputs are applied) and experimental data (to assess prediction capability of each model). Secondly, to propose changes in the models' structures to improve their transient and stationary responses. The versatility of the resulting model vs. the other two is shown according to the ability to simulate ventilatory stimuli, like exercise, with a proper regulation of the arterial blood gases, suitable constant times and a better adjustment to experimental data. The proposed model adjusts the breathing pattern every respiratory cycle using an optimization criterion based on minimization of work of breathing through regulation of respiratory f...Continue Reading

References

Jan 1, 1979·Annals of Biomedical Engineering·J L SpencerR B Mellins
Jun 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·D H Pearce, H T Milhorn
May 1, 1992·Journal of Applied Physiology·C S PoonO B Knudson
Oct 1, 1991·Immunology and Cell Biology·K J Turner
Jan 1, 1990·Journal of Applied Physiology·M C Khoo
Oct 23, 1965·Nature·I P Priban, W F Fincham
May 1, 1971·Journal of Applied Physiology·S M Yamashiro, F S Grodins
Jul 1, 1967·Journal of Applied Physiology·D J Read, J Leigh
Apr 1, 1983·Journal of Biomedical Engineering·W F Fincham, F T Tehrani
Jun 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·B J WhippK Wasserman
Jan 1, 1995·European Journal of Applied Physiology and Occupational Physiology·J H Mateika, J Duffin
Sep 1, 1994·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·J Duffin
Jul 1, 1994·Physiological Reviews·J M Marshall
Jan 4, 1998·Respiration Physiology·D L TurnerG S Mitchell
Oct 17, 1998·British Journal of Sports Medicine·B J Whipp, S A Ward
Nov 19, 2003·The European Respiratory Journal. Supplement·C Roussos, A Koutsoukou
Sep 15, 2004·Journal of Clinical Monitoring and Computing·Fleur TehraniMichael Terry
May 1, 1950·Journal of Applied Physiology·A B OTISH RAHN
Jan 18, 2006·Respiratory Physiology & Neurobiology·Philippe Haouzi
Mar 15, 2006·Respiratory Physiology & Neurobiology·Harold J Bell
Oct 17, 1913·The Journal of Physiology·A Krogh, J Lindhard
Feb 3, 2007·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·M MananasP Caminal
May 10, 2008·Journal of Applied Physiology·Eugene Nattie, Aihua Li
Apr 28, 2010·The Journal of Physiology·Gregory M BlainJerome A Dempsey
Jun 15, 2010·Respiratory Physiology & Neurobiology·Limei ChengMichael C K Khoo
Nov 26, 2010·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·Leidy Y SernaMiguel A Mananas
Nov 22, 2011·Respiratory Physiology & Neurobiology·Z CuiJ Duffin
Feb 1, 2012·Frontiers in Physiology·Limei Cheng, Michael C K Khoo
Apr 26, 2012·Journal of Clinical Monitoring and Computing·Fleur T Tehrani, Soraya Abbasi
Nov 6, 2012·Annual Review of Physiology·Jack L FeldmanPaul A Gray
Jan 1, 2012·Comprehensive Physiology·Prem Kumar, Nanduri R Prabhakar
Aug 14, 2013·The Journal of Physiology·James Duffin
Aug 30, 2013·Frontiers in Physiology·Paul J Fadel
Jan 3, 2014·Physiology·Diethelm W Richter, Jeffrey C Smith
Jun 14, 2014·The European Respiratory Journal·Jerome A Dempsey, Curtis A Smith
Oct 25, 2016·Journal of Theoretical Biology·Eric HermandJean-Paul Richalet
Jul 21, 2017·Journal of Neurophysiology·Casey O DiekmanChristopher G Wilson

❮ Previous
Next ❯

Citations

Jan 9, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Carlos Andrés SarmientoMiguel Ángel Mañanas
Jun 1, 2021·Computer Methods in Biomechanics and Biomedical Engineering·Jyoti Kori, Pratibha

❮ Previous
Next ❯

Software Mentioned

PNEUMA
RS3
RS2
Matlab

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.