An improved synthesis of psammaplin A.

Bioorganic & Medicinal Chemistry Letters
Amy M GodertJanice R Sufrin

Abstract

The marine natural product, psammaplin A, was first isolated from the Psammaplinaplysilla sponge in 1987. Since that time, psammaplin A has shown a wide spectrum of biological activities that include enzyme inhibitory activities resulting in antibacterial and antitumor effects. An improved synthesis of psammaplin A has been developed, making the compound more easily accessible for further biological evaluations. In this context, we find that psammaplin A is an effective DNA methyltransferase inhibitor in vitro but fails to alter genomic DNA methylation levels in treated human cancer cells.

References

Nov 1, 1995·Journal of Natural Products·J H JungC O Lee
Feb 12, 2002·Bioorganic & Medicinal Chemistry·J N TabudravuD M F van Aalten
Aug 6, 2002·Bioorganic & Medicinal Chemistry Letters·Gillian M NicholasCarole A Bewley
Jul 30, 2005·The Journal of Organic Chemistry·J Jonathan HarburnChristopher D Spilling

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Citations

Dec 20, 2011·Chemical Reviews·Cheng-Shi JiangYue-Wei Guo
Jan 28, 2012·Journal of Medicinal Chemistry·Matthias G J BaudMatthew J Fuchter
Dec 14, 2012·Organic Letters·Suresh K KottakotaJ Jonathan Harburn
Feb 6, 2008·Natural Product Reports·Jonathan C Morris, Andrew J Phillips
Mar 1, 2010·Genes & Cancer·Stefano AmatoriMirco Fanelli
Sep 2, 2008·Chemical & Pharmaceutical Bulletin·Makoto Yoshida, Kentaro Yamaguchi
Oct 6, 2009·Chemical & Pharmaceutical Bulletin·Makoto Yoshida, Kentaro Yamaguchi
Mar 16, 2012·Future Medicinal Chemistry·F CherblancM J Fuchter
Dec 4, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qianjiao YangLinxiang Zhao
Nov 30, 2010·Organic & Biomolecular Chemistry·Matthias G J BaudMatthew J Fuchter
Feb 12, 2013·Natural Product Reports·Fanny L CherblancMatthew J Fuchter
Aug 9, 2012·Organic & Biomolecular Chemistry·Fabia HentschelThomas Lindel
Mar 17, 2007·Journal of Natural Products·Yoichi Nakao, Nobuhiro Fusetani
Sep 13, 2012·Biochimie·Christina GrosPaola B Arimondo

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