An in-frame deletion in the alpha(2C) adrenergic receptor is common in African--Americans

Molecular Psychiatry
J FengS S Sommer

Abstract

alpha(2) adrenergic receptors are activated by adrenaline and noradrenaline, and three subtypes (ie, A, B, C) have differential affinities for antagonists and medications. The alpha(2c) adrenergic receptor (ADRA2C), located on chromosome 4p16.3, is a candidate gene for schizophrenia because it binds clozapine, an atypical neuroleptic useful for treatment-resistant schizophrenia. In addition, ADRA2C binds clonidine which is prescribed for three psychiatric diseases. This report communicates the findings of the genetic scanning of this gene of very tough GC content. The complete coding sequences and splice junctions were scanned with [DOVAM]-S in 104 schizophrenics, and pilot probes of patients with alcoholism (41 patients), cocaine abuse (25 patients), puerperal psychosis (30 patients), attention deficient/hyperactivity disorder (25 patients) and autism (25 patients). Six sequence variants were found, including five silent polymorphisms (allele frequencies 0.6--25%) and an in-frame deletion of a homologous repeat at nucleotides 967--978 (ie, TIDRU(1)). Genotyping of the normal two repeat unit of the Third Intracytoplasmic Domain Repeat Unit (TIDRU(2)) and the deleted variant (TIDRU(1)) revealed that TIDRU(1) had allelic frequenc...Continue Reading

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Citations

Jan 13, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alexander NeumeisterDennis S Charney
Apr 30, 2005·Pharmacogenetics and Genomics·Alexander NeumeisterDavid S Goldstein
Mar 24, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Guadalupe RiveroJ Javier Meana
Aug 10, 2001·American Journal of Medical Genetics·J GelernterS Goodson
Apr 27, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Vincenzo De LucaJames L Kennedy
Jun 24, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Akane ShibayamaSteve S Sommer
Sep 8, 2015·Nature Reviews. Microbiology·Antje BoetiusJosephine Z Rapp
Apr 21, 2019·Proceedings of the National Academy of Sciences of the United States of America·Sarah E MorganEdward T Bullmore
Dec 1, 2009·Heart Failure Clinics·Richard Sheppard

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