An in silico map of the SARS-CoV-2 RNA Structurome.

BioRxiv : the Preprint Server for Biology
Ryan J AndrewsWalter N Moss

Abstract

SARS-CoV-2 is a positive-sense single-stranded RNA virus that has exploded throughout the global human population. This pandemic coronavirus strain has taken scientists and public health researchers by surprise and knowledge of its basic biology (e.g. structure/function relationships in its genomic, messenger and template RNAs) and modes for therapeutic intervention lag behind that of other human pathogens. In this report we used a recently-developed bioinformatics approach, ScanFold, to deduce the RNA structural landscape of the SARS-CoV-2 transcriptome. We recapitulate known elements of RNA structure and provide a model for the folding of an essential frameshift signal. Our results find that the SARS-CoV-2 is greatly enriched in unusually stable and likely evolutionarily ordered RNA structure, which provides a huge reservoir of potential drug targets for RNA-binding small molecules. Our results also predict regions that are accessible for intermolecular interactions, which can aid in the design of antisense therapeutics. All results are made available via a public database (the RNAStructuromeDB) where they may hopefully drive drug discovery efforts to inhibit SARS-CoV-2 pathogenesis.

Citations

Jul 11, 2020·International Journal of Molecular Sciences·Ali Hosseini Rad Sm, Alexander D McLellan
Nov 10, 2020·Nucleic Acids Research·Anna WackerHeidi Zetzsche
Dec 4, 2020·Journal of Virology·Rafael de Cesaris Araujo TavaresAnna Marie Pyle
Dec 30, 2020·Viruses·Junxing ZhaoJingxin Wang
Dec 29, 2020·Biochemical Society Transactions·Ilaria Manfredonia, Danny Incarnato
Jan 13, 2021·Briefings in Bioinformatics·Md Asif AhsanMing Chen
May 27, 2021·Journal of the American Chemical Society·Sandro BottaroKresten Lindorff-Larsen

Datasets Mentioned

BETA
RF00507

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