An in silico platform for the study of epithelial pre-invasive neoplastic development

Bio Systems
Martial GuillaudCalum Macaulay

Abstract

To study the possible mechanisms of epithelial preneoplastic development we developed an integrated platform using a 3D agent-based model (ABM). This platform, named idefics, allows for the implementation of normal biological rules at the cell level that interact and generate the usual homeostatic equilibrium of epithelium as well as other abnormal processes that can disrupt this equilibrium. The structure of this model is based on data from multi-scale quantitative analysis of a unique collection of preneoplastic lesions of the lung, cervix, and oral epithelium, that have been collected in our lab in the last 25 years. In this paper, we are describing the different components of this platform and will present results from different simulations generated by the model.

References

Oct 1, 1976·Science·P C Nowell
Jul 1, 1996·The Journal of Pathology·J RashbassE D Williams
Jul 2, 2004·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Martial GuillaudCalum MacAulay
Sep 8, 2004·Bio Systems·D C WalkerR H Smallwood
Dec 23, 2004·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Martial GuillaudCalum E MacAulay
Mar 31, 2007·Nature Methods·Genee Y LeeMina J Bissell
Sep 18, 2007·Gynecologic Oncology·Clémence ThibervilleCalum MacAulay
Dec 29, 2007·Journal of Lower Genital Tract Disease·Olaf ReichSigrid Regauer

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Citations

Aug 9, 2013·Integrative Biology : Quantitative Biosciences From Nano to Macro·Claere von NeubeckMarianne B Sowa
Aug 1, 2014·Neoplasia : an International Journal for Oncology Research·Ana P BerbegallRosa Noguera
Jun 12, 2013·Seminars in Cancer Biology·Attila Csikász-NagyMatteo Cavaliere
Oct 10, 2015·PLoS Computational Biology·Bruce S GardinerDavid W Smith
Dec 7, 2016·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Vladimír UlmanPekka Ruusuvuori
Dec 2, 2017·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Calum MacAulayBranko Palcic

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