An in vitro evaluation of fluoxetine adsorption by activated charcoal and desorption upon addition of polyethylene glycol-electrolyte lavage solution

Journal of Toxicology. Clinical Toxicology
J Atta-PolitouM Koupparis

Abstract

In drug overdoses, treatment with activated charcoal is frequently used because of its adsorptive properties. Recently, whole-bowel irrigation with polyethylene glycol-electrolyte lavage solution has been used as a gastrointestinal decontamination procedure for ingestions of toxins not well adsorbed to activated charcoal and for toxins with a delayed absorption phase, although well adsorbed to activated charcoal. While a combined approach using activated charcoal and whole-bowel irrigation could theoretically enhance the efficacy of both modalities, this improvement remains speculative, since data demonstrating its clinical advantage in overdose treatment are lacking. Fluoxetine, a selective serotonin uptake inhibitor, is one of the most frequently prescribed antidepressants. Fluoxetine is well adsorbed onto activated charcoal. This in vitro investigation was undertaken to study: a) the effect of polyethylene glycol, as well as polyethylene glycol-electrolyte lavage solution, on the adsorption of fluoxetine to laboratory grade-activated charcoal and a commercial activated charcoal formulation (Carbomix powder) in simulated gastric (pH= 1.2) and intestinal (pH=7.2) fluid environment; b) whether the order of polyethylene glycol-e...Continue Reading

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Citations

Dec 13, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·J Atta-PolitouM Koupparis
May 31, 2001·Alimentary Pharmacology & Therapeutics·L R Schiller
May 7, 2002·Journal of Toxicology. Clinical Toxicology·Lotte Christine Groth HoegbergHanne R Christensen
Apr 13, 2005·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·P A ChykaUNKNOWN European Association of Poisons Centres and Clinical Toxicologists
Nov 10, 2004·Journal of Toxicology. Clinical Toxicology
Sep 15, 2004·Journal of Toxicology. Clinical Toxicology
Dec 17, 2014·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Ruben ThanacoodyBruno Mégarbane

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