PMID: 11909847Mar 23, 2002Paper

An in vitro evaluation of the antibiotic/heparin lock to sterilize central venous haemodialysis catheters

The Journal of Antimicrobial Chemotherapy
Lavern M VercaigneS Brian Penner

Abstract

This in vitro study investigated the ability of antibiotic/heparin locks to sterilize central venous haemodialysis catheters (CVCs) inoculated with methicillin-resistant Staphylococcus epidermidis (MRSE). Isolates of MRSE were incubated in broth inside CVCs. The catheters were then drained and filled with either vancomycin/gentamicin/heparin (VGH), cefazolin/gentamicin/ heparin (CGH) or control locks for 48 h. The catheters were drained, filled with fresh broth and again incubated. The final catheter solutions were sampled and the remaining volumes filtered. The samples, filters and catheter segments were examined for growth. For two isolates, both the VGH and CGH locks sterilized the catheters. Bacterial counts of the remaining two isolates were significantly reduced by >99%, but the catheters were not sterilized after the instillation of a single-antibiotic/heparin lock.

References

Sep 1, 1990·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A H MossD E McDowell
Jan 1, 1990·The Journal of Infectious Diseases·B F FarberA G Clogston
Nov 1, 1982·The Journal of Antimicrobial Chemotherapy·M P Slack, W W Nichols
Sep 1, 1994·The Journal of Infectious Diseases·R O DarouicheD M Musher
Jan 1, 1993·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·K Schaefer

❮ Previous
Next ❯

Citations

Jul 4, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Simone CesaroModesto Carli
Jul 9, 2003·Kidney International·Timothy DoultonDavid J A Goldsmith
Jan 16, 2007·Antimicrobial Agents and Chemotherapy·Saima AslamRabih O Darouiche
Jul 26, 2005·Infection and Immunity·Robert M Q ShanksGeorge A O'Toole
Jun 10, 2004·The Tohoku Journal of Experimental Medicine·Serkan OncuSerhan Sakarya
Sep 11, 2007·Infectious Disease Clinics of North America·Robert N Foley
Dec 23, 2015·SpringerPlus·Laure CalvetBrigitte Tardy-Poncet
Jul 4, 2006·Advances in Chronic Kidney Disease·Sakina B Naqvi, Allan J Collins
Dec 30, 2004·The Annals of Pharmacotherapy·Marisel Segarra-Newnham, Ellen M Martin-Cooper
Dec 4, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·P Brandon BookstaverRobert J Sherertz
Apr 6, 2006·The Journal of Vascular Access·M S Gersch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Related Papers

Antimicrobial Agents and Chemotherapy
Chirag B ShahLeonard A Mermel
The Tohoku Journal of Experimental Medicine
Serkan OncuHaluk Eraksoy
Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
T Bregenzer, A F Widmer
© 2022 Meta ULC. All rights reserved