Abstract
This in vitro study investigated the ability of antibiotic/heparin locks to sterilize central venous haemodialysis catheters (CVCs) inoculated with methicillin-resistant Staphylococcus epidermidis (MRSE). Isolates of MRSE were incubated in broth inside CVCs. The catheters were then drained and filled with either vancomycin/gentamicin/heparin (VGH), cefazolin/gentamicin/ heparin (CGH) or control locks for 48 h. The catheters were drained, filled with fresh broth and again incubated. The final catheter solutions were sampled and the remaining volumes filtered. The samples, filters and catheter segments were examined for growth. For two isolates, both the VGH and CGH locks sterilized the catheters. Bacterial counts of the remaining two isolates were significantly reduced by >99%, but the catheters were not sterilized after the instillation of a single-antibiotic/heparin lock.
References
Sep 1, 1990·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A H MossD E McDowell
Jan 1, 1990·The Journal of Infectious Diseases·B F FarberA G Clogston
Nov 1, 1982·The Journal of Antimicrobial Chemotherapy·M P Slack, W W Nichols
Sep 1, 1994·The Journal of Infectious Diseases·R O DarouicheD M Musher
Jan 1, 1993·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·K Schaefer
Aug 1, 1996·American Journal of Infection Control·M L Pearson
Aug 15, 1997·Annals of Internal Medicine·K A MarrK B Kirkland
Apr 20, 2000·Pharmacotherapy·L M VercaigneF J Burczynski
Citations
Jul 4, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Simone CesaroModesto Carli
Dec 28, 2012·International Urology and Nephrology·T N V SilvaD Ponce
Jul 9, 2003·Kidney International·Timothy DoultonDavid J A Goldsmith
Jan 16, 2007·Antimicrobial Agents and Chemotherapy·Saima AslamRabih O Darouiche
Jul 26, 2005·Infection and Immunity·Robert M Q ShanksGeorge A O'Toole
Jun 10, 2004·The Tohoku Journal of Experimental Medicine·Serkan OncuSerhan Sakarya
Dec 24, 2005·Kidney International·S H KimH K Kim
Sep 11, 2007·Infectious Disease Clinics of North America·Robert N Foley
Dec 23, 2015·SpringerPlus·Laure CalvetBrigitte Tardy-Poncet
Feb 15, 2008·Hemodialysis International·Jonathan CaseyPeter McClelland
Jul 4, 2006·Advances in Chronic Kidney Disease·Sakina B Naqvi, Allan J Collins
Jul 1, 2005·Current Therapeutic Research, Clinical and Experimental·Serkan Oncu, Serhan Sakarya
Feb 18, 2015·Future Microbiology·Azadeh MoghaddasHossein Khalili
Dec 30, 2004·The Annals of Pharmacotherapy·Marisel Segarra-Newnham, Ellen M Martin-Cooper
Dec 4, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·P Brandon BookstaverRobert J Sherertz
Apr 6, 2006·The Journal of Vascular Access·M S Gersch