May 1, 1976

An in vitro method for the study of beta-receptor mediated effects on slow contracting skeletal muscle

The Journal of Pharmacy and Pharmacology
B Waldeck


The soleus muscle of a guinea-pig was dissected out under pentobarbitone anaesthesia and mounted on a holder in an organ bath containing Krebs solution. The tendon was attached to a force transducer and subtetanic contractions were evoked by electrical field stimulation (0.5 ms pulses at 10-12 Hz for 1.5 or 3 s every 22 s). The experiments were performed at 37 degrees. Terbutaline, a selective agonist at beta2-adrenoceptors, reduced the force of subtetanic contractions in a dose-dependent manner, the EC50 being 0.2 muM. The reduction was due to a lessened degree of fusion. The results conform to previous in vivo studies.

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  • Citations20


Mentioned in this Paper

Physiologic Pulse
Contraction (Finding)
Adrenergic beta-Agonists
Soleus Muscle Structure
Terbutalin von ct
Adrenergic Receptor
Absence of Sensation
NEUROD1 wt Allele

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