PMID: 6168353Mar 15, 1981Paper

An in vitro model of human pancreas carcinogenesis: effects of nitroso compounds

Cancer
I ParsaA L Sutton

Abstract

It has been possible to maintain adult human pancreas in organ culture in a chemically defined medium. Under these conditions, all cell types demonstrated at least a limited ability to proliferate. This in vitro model was employed to study the effects of three nitroso compounds, DMNA, MNU, and BHP, on adult human pancreas. The major effects of three nitroso compounds, DMNA, MNU, and BHP, on adult human pancreas. The major effects of these compounds in cytotoxicity, proliferation, and oncogenicity was evaluated morphologically. DMNA and MNU were both carcinogenic but with varying rapidity of induction. MNU produced greater necrosis but gave more rapid induction. BHP produced cytotoxicity sufficient to prevent any rating of its oncogenic potential. Morphologically malignant tissue were tested for growth potential in nude mice. All nude mice developed multiple subcutaneous tumor nodules within eight weeks after inoculation. The tumor nodules ranged morphologically from undifferentiated scirrhous carcinoma to well-differentiated papillary adenocarcinoma.

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Citations

Jan 1, 1986·Biochimica Et Biophysica Acta·S E Chang
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M R Stampfer, J C Bartley
May 1, 1985·The Journal of Pathology·J ChenM A Ramsay
Jul 10, 2004·Biochemical Pharmacology·Diane J Lees MurdockChristopher R Barnett
Sep 11, 2019·QJM : Monthly Journal of the Association of Physicians·P LaoveeravatS Islam
Jan 14, 2020·Expert Opinion on Drug Safety·Nasser AlkhushaymIvo Abraham
Jul 3, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jessica L PetrickJulie R Palmer
Feb 1, 1991·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·B MonisM Rivolta
Jun 1, 1987·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·C Madahar, I Parsa

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